Hydrogen promotes the activation of Cu, Zn superoxide dismutase in a rat corneal alkali-burn model
Hydrogen promotes the activation of Cu, Zn superoxide dismutase in a rat corneal alkali-burn model
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DOI：
10.18240/ijo.2020.08.01
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发表时间：
2020-08-18
影响因子：
1.4
通讯作者：
Takahashi, Hiroshi
中科院分区：
文献类型：
--
作者：
Arima, Takeshi;Igarashi, Tsutomu;Takahashi, Hiroshi
目的：目的：观察氢（H-2）对角膜碱烧伤大鼠角膜Cu，Zn超氧化物歧化酶（SOD 1）活性的影响。生理盐水组（生理盐水组）或H-2溶解的生理盐水组（H-2组）在碱暴露前后持续滴注角膜5 min。炎症细胞，新血管形成，和细胞质SOD 1水平进行了化学评价从两组的眼球摘除。结果：H-2组角膜炎性细胞和血管内皮细胞数量均明显减少（P
AIM: To investigate the effects of hydrogen (H-2) on Cu, Zn superoxide dismutase (SOD1) activation in a rat model of corneal alkali burn.METHODS: In each rat, one cornea was subjected to alkali exposure. Physiological saline (saline group) or H-2-dissolved saline (H-2 group) was instilled continuously on the cornea for 5min before and after alkali exposure. Inflammatory cells, neovascularization, and cytoplasmic SOD1 levels were evaluated immunohistochemically in enucleated eyes from both groups. Three-dimensional ultrastructural tissue changes in the eyes were analyzed using low-vacuum scanning electron microscopy.RESULTS: The numbers of both inflammatory and vascular endothelial cells were significantly reduced in the corneas of the H-2 group (P