Sickle cell retinopathy in Jamaican children: further observations from a cohort study.
Sickle cell retinopathy in Jamaican children: further observations from a cohort study.
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牙买加儿童的镰状细胞性视网膜病：队列研究的进一步观察。
DOI：
10.1136/bjo.72.10.727
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Serjeant,GR
中科院分区：
文献类型：
--
作者：
Talbot,JF;Bird,AC;Maude,GH;Acheson,RW;Moriarty,BJ;Serjeant,GR
在镰状细胞病队列研究中，对5岁及以上儿童进行了一系列视网膜检查，对6岁及以上儿童进行了荧光素血管造影/血管镜检查。在389名5-13岁儿童中，观察了1229个患者年。在6岁时，大约50%的SS和SC基因型儿童存在周边视网膜血管闭合，并且在12岁时增加到影响90%的儿童。匹配对分析比较了最小闭合组和完全闭合组，表明完全闭合与SS疾病中总血红蛋白和胎儿血红蛋白水平显着降低以及体重显着降低相关，而在SC疾病中，风险因素似乎是高平均细胞体积和低血小板计数。视网膜病变是罕见的，只发生在一个8岁的男孩与SC疾病，尽管592患者年的观察超过这个年龄的儿童。
Serial retinal examinations were performed in children aged 5 years and older and fluorescein angiography/angioscopy in children 6 years and older participating in a cohort study of sickle cell disease. There were 1229 patient years of observation among 389 children aged 5-13 years. Peripheral retinal vessel closure was present in approximately 50% of children with SS and SC genotypes at age 6 years and increased to affect 90% of children by age 12 years. A matched pair analysis, comparing groups with minimal and complete closure, indicated that complete closure was associated with significantly lower total haemoglobin and fetal haemoglobin levels and significantly lower weight in SS disease, whereas in SC disease the risk factors appeared to be high mean cell volume and low platelet count. Proliferative retinopathy was rare, occurring only once in an 8-year-old boy with SC disease, despite 592 patient years of observation in children over this age.