Magnetizable implants and functionalized magnetic carriers: A novel approach for noninvasive yet targeted drug delivery
Magnetizable implants and functionalized magnetic carriers: A novel approach for noninvasive yet targeted drug delivery
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DOI：
10.1016/j.jmmm.2005.01.087
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发表时间：
2005-05-01
影响因子：
2.7
通讯作者：
Ritter, JA
中科院分区：
文献类型：
--
作者：
Rosengart, AJ;Kaminski, MD;Ritter, JA
我们描述了一种靶向给药系统，包括两个步骤：第一，静脉注射和循环的生物相容性，磁性纳米球封装的药物;和第二，焦点浓度和释放的药物在目标部位利用植入的，可磁化的腔内支架或种子。我们介绍了系统的概念，概述了生物医学的可行性，并讨论了潜在的临床优势。(c)2005年由Elsevier B. V.出版
We describe a targeted drug delivery system consisting of two steps: first, intravenous injection and circulation of biocompatible, magnetic nanospheres encapsulated with a drug; and second, focal concentration and release of the drug at the target site utilizing an implanted, magnetizable intraluminal stent or seed. We introduce the system concept, outline the biomedical feasibility, and discuss potential clinical advantages. (c) 2005 Published by Elsevier B.V.