Normal CSF oxytocin and NPY levels in OCD
Normal CSF oxytocin and NPY levels in OCD
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DOI：
10.1016/s0006-3223(98)00263-7
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发表时间：
1999-04-01
影响因子：
10.6
通讯作者：
Gold, PW
中科院分区：
文献类型：
--
作者：
Altemus, M;Jacobson, KR;Gold, PW
背景：最近人们关注的焦点是中枢神经系统神经肽作为强迫症（OCD）症状特征的潜在介质。据报道，强迫症患者脑脊液中抗焦虑神经肽催产素水平升高。脑脊液中另一种抗焦虑神经肽NPY的水平尚未得到研究。方法：对14例强迫症患者和26例健康正常人进行脑脊液催产素和NPY测定。结果：强迫症患者脑脊液催产素和NPY水平与对照组无显著差异。在强迫症和对照组中，女性的脑脊液催产素水平明显高于男性。结论：这些结果不支持强迫症患者脑脊液催产素升高的先前发现，也没有提供强迫症患者NPY调节异常的任何证据。生物精神病学1999；[5]中华医学会精神病学分会。
Background: Attention has recently been focused on central nervous system neuropeptides as potential mediators of th symptom profile of obsessive-compulsive disorder (OCD). Increased CSF levels of the anxiolytic neuropeptide oxytocin have been reported in OCD. CSF levels of NPY, another anxiolytic neuropeptide, have not been studied.Methods: We measured CSF oxytocin and NPY in 14 OCD patients and 26 healthy normal volunteers.Results: There were no significant differences between the OCD patients and control subjects in CSF oxytocin or NPY levels. In both the OCD and control groups, women had significantly higher CSF oxytocin levels than men.Conclusions: These results do not support a prior finding of elevated CSF oxytocin in OCD patients and do not provide any evidence for an abnormality of NPY regulation in OCD. Biol Psychiatry 1999;45:931-933 (C) 1999 Society of Biological Psychiatry.