Dopamine and iron in the pathophysiology of restless legs syndrome (RLS)
Dopamine and iron in the pathophysiology of restless legs syndrome (RLS)
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DOI：
10.1016/j.sleep.2004.01.012
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发表时间：
2004-07-01
期刊：
影响因子：
4.8
通讯作者：
Allen, R
中科院分区：
文献类型：
--
作者：
Allen, R
背景和目的：对不宁腿综合征(RLS)的病理生理学评价在很大程度上源于对疾病的药物治疗和疾病的继发性形式所提供的信息的认识。本文探讨了RLS的这些临床方面的病理生理学意义。患者和方法：本文回顾了与临床数据提示的可能的病理有关的现有文献。然后，它将探索支持每一种可能的病理的其他数据，并检查这些病理之间的关系。结果：药物治疗数据强烈支持RLS的多巴胺能异常。其他药理学数据和一些成像数据也支持这一点，尽管数据并不完全一致。RLS的继发性形式强烈支持RLS的缺铁异常，其他几项研究进一步证实了这一点。一些动物研究表明，铁缺乏与多巴胺能异常之间的关系与RLS患者的情况有一些相似之处。结论：至少在部分或大多数RLS患者中，可能存在铁-多巴胺联系的病理生理学中心。(C)2004爱思唯尔B.V.保留所有权利。
Background and purpose: The evaluation of the pathophysiology of restless legs syndrome (RLS) stems largely from recognition of the information provided by both pharmacological treatment of the disorder and the secondary forms of the disorder. This article examines the pathophysiological implications of each of these clinical aspects of RLS.Patients and methods: The article reviews the existing literature in relation to possible pathology suggested by the clinical data. It will then explore other data supporting each of the possible pathologies and examine the relationships between these pathologies.Results: The pharmacological treatment data strongly support a dopaminergic abnormality for RLS. Other pharmacological data and some imaging data also support this, although the data are not entirely consistent. The secondary forms of RLS strongly support an iron deficiency abnormality for RLS, further documented by several other studies. Some animal studies have shown a relation between iron deficiency and dopaminergic abnormalities that have some similarity to those seen in the RLS patient.Conclusions: It is concluded that there may be an iron-dopamine connection central to the pathophysiology of RLS for at least some if not most patients with this disorder. (C) 2004 Elsevier B.V. All rights reserved.