Higher chromosomal abnormality rate in blastocysts from young patients with idiopathic recurrent pregnancy loss
Higher chromosomal abnormality rate in blastocysts from young patients with idiopathic recurrent pregnancy loss
复制标题
年轻特发性复发性流产患者囊胚染色体异常率较高
DOI：
10.1016/j.fertnstert.2019.11.016
复制
发表时间：
2020-04-01
影响因子：
6.7
通讯作者：
Xu, Yan-Wen
中科院分区：
文献类型：
--
作者：
Liu, Xin-Yan;Fan, Qi;Xu, Yan-Wen
Objective: To determine whether the incidence of chromosomal abnormalities in blastocysts is higher in patients with idiopathic recurrent pregnancy loss (iRPL) who underwent preimplantation genetic testing for aneuploidy (PGT-A) than in those who underwent preimplantation genetic testing for monogenic defects (PGT-M).Design: Retrospective cohort study.Setting: University-affiliated reproductive center.Patient(s): A total of 62 patients with iRPL underwent 101 PGT-A cycles (iRPL group), and 212 patients underwent 311 PGT-M cycles (control group).Interventions(s): Blastocyst biopsy and comprehensive chromosome screening technologies, including single-nucleotide polymorphism microarrays and next-generation sequencing.Main Outcome Measure(s): Incidence of chromosomal abnormalities in blastocysts and clinical miscarriage (CM) rate.Result(s): Stratification analysis by maternal age showed an increased incidence of chromosomal abnormalities in the iRPL group aged 35 years (66.9% vs. 61.4%). After transfer of euploid embryos, women aged
