Obstructive Sleep Apnea Exacerbates Glucose Dysmetabolism and Pancreatic 0-Cell Dysfunction in Overweight and Obese Nondiabetic Young Adults
Obstructive Sleep Apnea Exacerbates Glucose Dysmetabolism and Pancreatic 0-Cell Dysfunction in Overweight and Obese Nondiabetic Young Adults
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阻塞性睡眠呼吸暂停会加剧超重和肥胖非糖尿病年轻人的葡萄糖代谢异常和胰腺 0 细胞功能障碍
DOI：
10.2147/dmso.s250463
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发表时间：
2020-01-01
期刊：
影响因子：
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通讯作者：
Li, Qing Yun
中科院分区：
文献类型：
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作者：
Li, Ning;Fan, Yun;Li, Qing Yun
目的：本研究旨在探讨阻塞性睡眠呼吸暂停（OSA）对胰腺β细胞功能障碍的影响及其在超重和肥胖非糖尿病年轻人糖代谢异常中的意义。材料和方法：横断面分析包括422名受试者（261名男性/161名女性），平均年龄为27.77 +/- 7.51岁，平均体重指数（BMI）为34.84 +/- 5.69 kg/m2。所有受试者均行多导睡眠图（PSG）、口服葡萄糖耐量-胰岛素释放试验（OGTT-IRT）和糖化血红蛋白A1（HbA 1c）测定。结果：正常糖耐量（NGT）组OSA发生率为54.91%，糖尿病前期（preDM）组OSA发生率为72.11%（P=0.001）。糖尿病前期合并重度OSA者HbA 1c最高。在NGT组中，1小时血糖水平随着OSA严重程度的增加而显著升高，稳态模型评估β（HOMA β）与夜间平均SpO（2）呈负相关（P
Purpose: This study aimed to investigate the effects of obstructive sleep apnea (OSA) on the pancreatic beta-cells dysfunction and their implications in the glucose dysmetabolism of overweight and obese nondiabetic young adults.Materials and Methods: The cross-sectional analysis included 422 subjects (261 males/161 females) with the mean age of 27.77 +/- 7.51 years and average body mass index (BMI) of 34.84 +/- 5.69 kg/m(2). All subjects underwent polysomnography (PSG), oral glucose toleranceinsulin releasing test (OGTT-IRT) and serum glycosylated hemoglobin A1 (HbA1c) measurement. The glucose metabolism and pancreatic beta-cell function in relation to measures of OSA were determined adjustment for important confounders such as age and sex.Results: OSA subjects accounted for 54.91% in the normal glucose tolerance (NGT) group and 72.11% in the prediabetes (preDM) group (P=0.001). HbA1c was the highest in the preDM subjects with severe OSA. In the NGT subjects, the 1-h glucose level significantly elevated with the OSA severity, and the homeostasis model assessment-beta (HOMA-beta) was negatively related to nocturnal mean SpO(2) (P