Mechanochemistry for the production of a hybrid salt used in the treatment of malaria
Mechanochemistry for the production of a hybrid salt used in the treatment of malaria
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DOI：
10.1039/c9gc02478f
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发表时间：
2020-01-07
期刊：
影响因子：
9.8
通讯作者：
Ferreira, Fabio F.
中科院分区：
文献类型：
--
作者：
do Prado, Vania M.;de Queiroz, Thiago B.;Ferreira, Fabio F.
机械化学是指由涉及固体的机械能引起的化学反应。这种方法提供了几个优于溶液相合成的优点，例如最大限度地减少了化学反应中对大量溶剂的需求，以及更绿色和更有效的合成溶液。在本文中，我们获得，通过机械化学，一个混合盐，命名为MEFAS，来自两个抗疟分子-甲氟喹和青蒿琥酯。我们证明，使用一个简单的实验程序，如何在机械化学反应过程中存在的液体的催化量是决定性的，以获得MEFAS。傅里叶变换红外光谱（FTIR）和核磁共振（NMR）数据表明，液体辅助的机械化学反应是有前途的混合盐的形成，这是通过青蒿琥酯分子的羧酸基团与甲氟喹的哌啶基团的氢相互作用形成的。
Mechanochemistry refers to a chemical reaction induced by mechanical energy involving solids. This method provides several advantages over solution-phase synthesis, such as minimizing the need for large volumes of solvents in chemical reactions and greener and more efficient synthetic solutions. In this paper we obtain, via mechanochemistry, a hybrid salt, named MEFAS, derived from two antimalarial molecules - mefloquine and artesunate. We demonstrate, using a simple experimental procedure, how the catalytic amount of liquid present during mechanochemical reactions is decisive to obtain MEFAS. Fourier-transform infrared spectroscopy (FTIR) and nuclear magnetic resonance (NMR) data indicate that liquid-assisted mechanochemical reactions are promising in the formation of the hybrid salt, which is formed via a hydrogen interaction of the carboxylate group of the artesunate molecule with the piperidine group of mefloquine.