Effects of prostaglandin E1 on oxygen delivery and consumption in patients with the adult respiratory distress syndrome. Results from the prostaglandin E1 multicenter trial. The Prostaglandin E1 Study Group.
Effects of prostaglandin E1 on oxygen delivery and consumption in patients with the adult respiratory distress syndrome. Results from the prostaglandin E1 multicenter trial. The Prostaglandin E1 Study Group.
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前列腺素 E1 对成人呼吸窘迫综合征患者氧输送和消耗的影响。
DOI：
10.1378/chest.98.2.405
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发表时间：
1990
期刊：
影响因子：
9.6
通讯作者：
J. Ursprung
中科院分区：
文献类型：
--
作者：
Henry J. Silverman;G. Slotman;R. C. Bone;Richard J. Maunder;T. M. Hyers;Morris D. Kerstein;J. Ursprung
我们想确定持续输注PGE 1对ARDS患者DO 2和VO 2的长期影响。数据来自一项随机双盲多中心试验，该试验评价了PGE 1对ARDS患者生存率的影响。根据治疗和结局对患者进行分层：安慰剂组死亡（n = 8）; PGE 1组死亡（n = 12）;安慰剂组存活（n = 9）; PGE 1组存活（n = 8）。在安慰剂死亡组中，VO 2升高，这与O2 ext增加和DO 2恒定相关。相反，在PGE 1死亡组中，VO 2升高与DO 2增加和O2 ext不变相关。在安慰剂存活组中，VO 2和DO 2降低，而在PGE 1存活组中，VO 2和DO 2增加;然而，这两组的O2 ext均降低。由于O2 ext受损发生在ARDS中，PGE 1诱导的DO 2升高，而不是O2 ext的代偿性增加，可能会获得更好的组织氧合。我们的结论是，虽然最近完成的多中心试验未能显示前列腺素E1对晚期ARDS患者的生存率的增强作用，前列腺素E1可能对氧转运有重要影响，因此，可能仍然有作用，在治疗早期表现的ARDS，无论是单独或与其他药物联合使用。
We wanted to determine the long-term effects of a continuous infusion of PGE1 on DO2 and VO2 in patients with ARDS. Data were obtained from a randomized double-blind multicenter trial, which evaluated the effects of PGE1 on survival in patients with ARDS. Patients were stratified according to treatment and outcome: placebo-died (n = 8); PGE1-died (n = 12); placebo-survived (n = 9); and PGE1-survived (n = 8). In the placebo-died group, elevations occurred in VO2, which were associated with increases in O2ext and a constant DO2. In contrast, in the PGE1-died group, elevations in VO2 were associated with increases in DO2 and an unchanged O2ext. In the placebo-survived group, VO2 and DO2 decreased, whereas in the PGE1-survived group, VO2 and DO2 increased; however, O2ext decreased in both of these groups. Since impaired O2ext occurs in ARDS, PGE1-induced elevations in DO2, rather than compensatory increases in O2ext, may achieve better tissue oxygenation. We conclude that although the recently completed multicenter trial failed to show an enhancing effect of PGE1 on survival in patients with advanced ARDS, PGE1 may have important effects on oxygen transport and, therefore, may still have a role in the treatment of early manifestations of ARDS, either alone or in combination with other agents.