Assessing retino-geniculo-cortical connectivities in Alzheimer's Disease with a neural mass model
Assessing retino-geniculo-cortical connectivities in Alzheimer's Disease with a neural mass model
复制标题
用神经质量模型评估阿尔茨海默氏病的视网膜-膝部-皮质连接
DOI：
10.1109/ccmb.2011.5952125
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
L. Maguire
中科院分区：
文献类型：
--
作者：
B. Bhattacharya;D. Coyle;L. Maguire
纵向研究表明，theta 频带内平均频率的增加可能被认为是进展为阿尔茨海默病 (AD) 的早期症状。此外，α 频段内平均频率的减慢早已被认为是 AD 的一个明确标志。这项工作旨在更好地了解 AD 脑电图 (EEG) 变化背后的神经元连接变化。具体来说，使用神经质量计算模型研究背外侧膝皮质通路的连接变化。模型中的连接参数由哺乳动物外侧膝状核（背侧）的最新实验数据提供。随着丘脑内和丘脑皮质通路中兴奋性和抑制性参数的增加以及感觉通路突触连接性的减少，观察到模型输出的平均功率谱减慢。结果的生物学合理性表明 AD 研究中模型进一步扩展的潜力。
Longitudinal studies have shown that increase of mean frequency within the theta band may be considered as an early symptom of progression into Alzheimer's Disease (AD). Also, slowing of mean frequency within the alpha band has long since been known to be a def nitive marker in AD. This work is aimed at developing a better understanding of alterations in neuronal connectivity underlying Electroencephalogram (EEG) changes in AD. Specif cally, connectivity changes in the dorso-lateral geniculo-cortical pathway are studied using a neural mass computational model. Connectivity parameters in the model are informed by the most recent experimental data on mammalian Lateral Geniculate Nucleus (dorsal). A slowing of the mean power spectra of the model output is observed with increase in both excitatory and inhibitory parameters in the intra-thalamic and thalamocortical pathways and a decrease of sensory pathway synaptic connectivity. The biological plausibility of the results suggest potential of further model extension in AD research.