Economic Evaluation in Opioid Modeling: Systematic Review.
Economic Evaluation in Opioid Modeling: Systematic Review.
复制标题
阿片类药物建模的经济评价：系统评价。
DOI：
10.1016/j.jval.2020.07.013
复制
发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Jalali MS
中科院分区：
文献类型：
--
作者：
Beaulieu E;DiGennaro C;Stringfellow E;Connolly A;Hamilton A;Hyder A;Cerdá M;Keyes KM;Jalali MS
过去20年来，阿片类药物过量和阿片类药物使用障碍（OUD）的迅速增加是一个复杂的问题，与医疗保健系统和社会的重大经济成本相关。已经开发了模拟模型来捕获和识别管理这种复杂性的方法，并评估不同策略的潜在成本，以减少过量和OUD。一个基于模拟的经济评价的审查是必要的，以充分表征这套文献。通过检索PubMed、EMBASE和EbscoHOST，对阿片类药物研究中基于模拟的经济评价（SBEE）研究进行了系统综述。对每项研究提取预定义的项目集并进行质量评估。筛选过程产生了23个SBEE研究，从1999年到2019年按出版年份排列。成本分析的方法质量较高。最常评价的策略是美沙酮和丁丙诺啡维持治疗;唯一探讨的减少伤害策略是纳洛酮分配。这些策略一直被认为是具有成本效益的，特别是纳洛酮分配和美沙酮维持。预防战略仅限于滥用威慑类阿片制剂。不到一半（39%）的分析在估计阿片类药物相关干预的成本和影响时采用了社会视角。在这些SBEE中，预防策略和研究对患者和医生偏好、费用变化或结果分层的解释在很大程度上被忽视。该综述显示了纳洛酮分配策略和阿片类激动剂治疗的一贯有利的成本分析结果，并确定了未来研究的主要差距。
The rapid increase in opioid overdose and opioid use disorder (OUD) over the past 20 years is a complex problem associated with significant economic costs for healthcare systems and society. Simulation models have been developed to capture and identify ways to manage this complexity, and to evaluate the potential costs of different strategies to reduce overdoses and OUD. A review of simulation-based economic evaluations is warranted to fully characterize this set of literature. A systematic review of simulation-based economic evaluation (SBEE) studies in opioid research was initiated by searches in PubMed, EMBASE, and EbscoHOST. Extraction of a pre-defined set of items and a quality assessment were performed for each study. The screening process resulted in 23 SBEE studies ranging by year of publication from 1999 to 2019. Methodological quality of the cost analyses was moderately high. The most frequently evaluated strategies were methadone and buprenorphine maintenance treatments; the only harm reduction strategy explored was naloxone distribution. These strategies were consistently found to be cost-effective, especially naloxone distribution and methadone maintenance. Prevention strategies were limited to abuse-deterrent opioid formulations. Less than half (39%) of analyses adopted a societal perspective in their estimation of costs and effects from an opioid-related intervention. Prevention strategies and studies’ accounting for patient and physician preference, changing costs, or result stratification were largely ignored in these SBEEs. The review shows consistently favorable cost analysis findings for naloxone distribution strategies and opioid agonist treatments, and identifies major gaps for future research.
登录
查看更多内容
影响因子：
3.7
作者：
Chetty M;Kenworthy JJ;Langham S;Walker A;Dunlop WC
通讯作者：
Dunlop WC
影响因子：
6
作者：
Barnett, PG
通讯作者：
Barnett, PG
影响因子：
10.5
作者：
Haasen, Christian;Verthein, Uwe;Naber, Dieter
通讯作者：
Naber, Dieter
影响因子：
--
作者：
Castillo, Tessie
通讯作者：
Castillo, Tessie
影响因子：
39.2
作者：
Coffin, Phillip O.;Sullivan, Sean D.
通讯作者：
Sullivan, Sean D.