Dietary Vitamin C Deficiency Is Associated With Health-Related Quality of Life and Cardiac Event-free Survival in Adults With Heart Failure.
Dietary Vitamin C Deficiency Is Associated With Health-Related Quality of Life and Cardiac Event-free Survival in Adults With Heart Failure.
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膳食维生素 C 缺乏与心力衰竭成人的健康相关生活质量和无心脏事件生存有关。
DOI：
10.1097/jcn.0000000000000521
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发表时间：
2019
期刊：
影响因子：
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通讯作者：
Lennie,TerryA
中科院分区：
文献类型：
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作者：
Wu,Jia-Rong;Song,EunKyeung;Moser,DebraK;Lennie,TerryA
背景：成人心力衰竭（HF）患者普遍缺乏维生素C。关于膳食维生素C缺乏与成年心衰患者健康结局的关系，我们知之甚少。目的：该研究的目的是确定基线时测量的维生素C缺乏与HF患者1年后测量的健康相关生活质量（HRQOL）和无心脏事件生存的关系。方法：251例心衰患者完成了为期4天的饮食日记。膳食维生素C缺乏症被定义为每日摄入量低于美国医学研究所（Institute of Medicine）估计的平均需要量（男性75毫克/天，女性60毫克/天）。12个月时使用明尼苏达心力衰竭患者生活问卷评估与健康相关的生活质量。患者随访时间中位数为1年，以确定首次发生心脏相关住院或死亡事件的时间。采用分层线性和Cox比例风险回归分析数据。结果：100例（40%）患者存在维生素C缺乏症。饮食中维生素C缺乏与12个月时较差的HRQOL相关(β= 0.16， P=。02)在控制了人口统计学和临床变量后。在随访期间，59名患者（24%）发生心脏事件。在Cox回归中，在调整相同协变量后，维生素C缺乏预测较短的无心脏事件生存期（风险比，1.95；95%可信区间，1.08-3.51）。结论：缺乏维生素C与心衰患者较差的HRQOL和较短的无心脏事件生存期有关。研究结果表明，鼓励心衰患者食用富含水果/蔬菜的饮食以预防维生素C缺乏症可能会带来更好的健康结果。
Background:Vitamin C deficiency is prevalent in adults with heart failure (HF). Little is known about the relationship of dietary vitamin C deficiency with health outcomes in adults with HF.Objective:The study’s aim was to determine the relationships of vitamin C deficiency measured at baseline with health-related quality of life (HRQOL) and cardiac event-free survival in patients with HF measured 1 year later.Method:A total of 251 patients with HF completed a 4-day food diary. Dietary vitamin C deficiency was defined as daily intake less than the estimated average requirement from the Institute of Medicine of 75 mg/d for men and 60 mg/d for women. Health-related quality of life was assessed using the Minnesota Living with Heart Failure Questionnaire at 12 months. Patients were followed for a median of 1 year to determine time to the first event of cardiac-related hospitalization or death. Data were analyzed by hierarchical linear and Cox proportional hazards regressions.Results:One hundred patients (40%) had vitamin C deficiency. Dietary vitamin C deficiency was associated with poorer HRQOL at 12 months (β= 0.16, P=. 02) after controlling for demographic and clinical variables. During the follow-up period, 59 patients (24%) had cardiac events. In Cox regression, vitamin C deficiency predicted shorter cardiac event-free survival after adjusting for the same covariates (hazards ratio, 1.95; 95% confidence interval, 1.08–3.51).Conclusion:Vitamin C deficiency was associated with poorer HRQOL and shorter cardiac event-free survival in patients with HF. The findings suggest that encouraging patients with HF to consume a diet rich in fruits/vegetables to prevent vitamin C deficiency may lead to better health outcomes.