Prevention and control of thalassemia in Ramathibodi Hospital, Thailand.
Prevention and control of thalassemia in Ramathibodi Hospital, Thailand.
复制标题
泰国拉马蒂博迪医院地中海贫血的预防和控制。
DOI：
--
复制
发表时间：
2000
期刊：
影响因子：
--
通讯作者：
R. Rungsiprakarn
中科院分区：
文献类型：
--
作者：
A. Jaovisidha;S. Ajjimarkorn;P. Panburana;O. Somboonsub;Y. Herabutya;R. Rungsiprakarn
8736名孕妇进行了地中海贫血和血红蛋白病的筛查，平均红细胞体积小于80飞升（fl）。3670名女性（42%）MCV小于80 fl.在该组中，有2,390名女性（70%）通过高效液相色谱法（HPLC）进行了阳性Hb分型，如重型β-地中海贫血、β-地中海贫血血红蛋白E病、β-地中海贫血性状、杂合子和纯合子血红蛋白E，α地中海贫血1型和血红蛋白H疾病，77%的伴侣来做了血红蛋白分型。75对夫妇的风险，有严重影响地中海贫血胎儿被检测到从这个筛选程序。58对夫妇（77.3%）进行了产前诊断。检测到8只受累胎仔。除1例β-地中海贫血/HbE外，所有受影响胎儿的妊娠均终止。有3例胎儿丢失（6%）的结果，产前诊断程序。
Eight thousand seven hundred and thirty-six pregnant women were screened for thalassemia and hemoglobinopathies by mean corpuscular volume less than 80 femtolitres (fl). Three thousand six hundred and seventy women (42%) were MCV less than 80 fl. In this group there were 2,390 women (70%) who had positive Hb typing by high performance liquid chromatography (HPLC) such as beta-thalassemia major, beta-thalassemia hemoglobin E disease, beta-thalassemia trait, heterozygous and homozygous hemoglobin E, alpha-thalassemia-1 trait and hemoglobin H disease and 77% of their partners came and had hemoglobin typing done. Seventy-five couples at risk for having severely affected thalassemia fetuses were detected from this screening program. Prenatal diagnosis was performed in 58 couples (77.3%). Eight affected fetuses were detected. All pregnancies with affected fetuses except one with beta-thalassemia/HbE were terminated. There were 3 fetal losses (6%) as the result of prenatal diagnosis procedure.