Visual Acuity Development and Plasticity in the Absence of Sensory Experience
Visual Acuity Development and Plasticity in the Absence of Sensory Experience
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DOI：
10.1523/jneurosci.1500-13.2013
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发表时间：
2013-11-06
影响因子：
5.3
通讯作者：
Fagiolini, Michela
中科院分区：
文献类型：
--
作者：
Kang, Erin;Durand, Severine;Fagiolini, Michela
视觉回路在感官体验的作用下成熟和完善。然而，我们对剥夺如何影响小鼠视力发展的理解仍存在重大差距。在这里，我们进行了一项纵向研究，评估慢性剥夺对小鼠皮层下和皮层视觉回路的发展的影响，使用行为optomotor测试，在体内视觉诱发反应（VEP）和单单位皮层记录的组合。如前所述，方向调谐退化，眼优势可塑性的发生延迟，并保持开放，在慢性剥夺小鼠。令人惊讶的是，我们发现，视动阈值和VEP敏锐度的发展可以发生在一个经验独立的方式，虽然在一个显着较慢的速度。此外，单眼剥夺只在黑暗中的一个离散的发展时期引起弱视。剥夺小鼠暴露于光后的视运动阈值的恢复率证实了成熟的过渡，无论视觉输入。总之，我们的研究结果揭示了一个可分离的发展轨迹，在黑暗中饲养的小鼠的视觉感受场的特性，这表明丘脑皮质和皮质内电路的自发活动的差异作用。
Visual circuits mature and are refined by sensory experience. However, significant gaps remain in our understanding how deprivation influences the development of visual acuity in mice. Here, we perform a longitudinal study assessing the effects of chronic deprivation on the development of the mouse subcortical and cortical visual circuits using a combination of behavioral optomotor testing, in vivo visual evoked responses (VEP) and single-unit cortical recordings. As previously reported, orientation tuning was degraded and onset of ocular dominance plasticity was delayed and remained open in chronically deprived mice. Surprisingly, we found that the development of optomotor threshold and VEP acuity can occur in an experience-independent manner, although at a significantly slower rate. Moreover, monocular deprivation elicited amblyopia only during a discrete period of development in the dark. The rate of recovery of optomotor threshold upon exposure of deprived mice to light confirmed a maturational transition regardless of visual input. Together our results revealed a dissociable developmental trajectory for visual receptive-field properties in dark-reared mice suggesting a differential role for spontaneous activity within thalamocortical and intracortical circuits.