FORMATION OF PARALLEL 4-STRANDED COMPLEXES BY GUANINE-RICH MOTIFS IN DNA AND ITS IMPLICATIONS FOR MEIOSIS
FORMATION OF PARALLEL 4-STRANDED COMPLEXES BY GUANINE-RICH MOTIFS IN DNA AND ITS IMPLICATIONS FOR MEIOSIS
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DOI：
10.1038/334364a0
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发表时间：
1988-07-28
期刊：
影响因子：
64.8
通讯作者：
GILBERT, W
中科院分区：
文献类型：
--
作者：
SEN, D;GILBERT, W
我们发现，含有富含鸟嘌呤的短基序的单链DNA在生理盐浓度下会自我缔合，形成四链结构，其中链以平行方式运行。我们相信这些复合物是由鸟嘌呤通过Hoogsteen配对结合在一起的。这种富含鸟嘌呤的序列出现在免疫球蛋白开关区1，基因启动子2，3和染色体端粒4。我们推测，这种富含鸟嘌呤的DNA基序的自我识别有助于在减数分裂过程中将四个同源染色单体聚集在一起，并在寄存器中拉链。
We have discovered that single-stranded DNA containing short guanine-rich motifs will self-associate at physiological salt concentrations to make four-stranded structures in which the strands run in parallel fashion. We believe these complexes are held together by guanines bonded to each other by Hoogsteen pairing. Such guanine-rich sequences occur in immunoglobulin switch regions1, in gene promoters2,3, and in chromosomal telomeres4. We speculate that this self-recognition of guanine-rich motifs of DNA serves to bring together, and to zipper up in register, the four homologous chromatids during meiosis.