Measured height loss predicts fractures in middle-aged and older men and women: The EPIC-Norfolk prospective population study
Measured height loss predicts fractures in middle-aged and older men and women: The EPIC-Norfolk prospective population study
复制标题
DOI：
10.1359/jbmr.071106
复制
发表时间：
2008-03-01
影响因子：
6.2
通讯作者：
Khaw, Kay-Tee
中科院分区：
文献类型：
--
作者：
Moayyeri, Alireza;Luben, Robert N.;Khaw, Kay-Tee
在这项针对中老年男性和女性的大规模人群前瞻性研究中，我们发现4年内身高下降>2 cm是未来骨折的重要预测因素。因此，建议在老年人中连续测量身高。引言：身高变化可以很容易地测量，并可能有助于骨折风险预测。我们评估了测量身高损失和骨折发病率在前瞻性population study.Materials和方法：身高测量的参与者在诺福克队列的欧洲前瞻性调查癌症（EPIC-诺福克）在1993年和1997年之间，并在1997年和2000年之间重复。2006年的骨折事件通过医院记录linking.Results确定：在14,921名42-82岁的男性和女性中，在平均7.1年的随访期内，有390例骨折，包括122例髋部骨折。有骨折史的受试者的既往年身高损失（1.8 +/- 0.3 [SD] mm）显著大于其他受试者（0.9 +/- 0.2 mm; p < 0.001）。年身高损失>0.5 cm的参与者与身高没有损失的参与者相比，任何骨折的年龄和性别调整风险比为1.76（95%CI，1.16-2.67），髋部骨折为2.08（95%CI，1.07-4.05）。调整年龄、性别、既往骨折史、吸烟、体重指数、饮酒和足跟超声测量后，身高每减少1 cm/年，所有骨折的风险比为1.86（95%CI，1.28-2.72），髋部骨折的风险比为2.24（95%CI，1.23-4.09）。每年身高损失1厘米是有骨折的历史，相当于类似的14岁以上的实际年龄在骨折risk.Conclusions的关系的大小方面：中年和老年男性和女性每年身高损失>0.5削减髋部和任何骨折的风险增加。连续的高度测量可以有助于骨折风险预测。
In this large population-based prospective study among middle-aged and older men and women, we found that height loss of >2 cm over a period of 4 yr is a significant predictor of future fractures. Serial measurement of height is, therefore, recommended among the elderly people.Introduction: Height change can be easily measured and may contribute to fracture risk prediction. We assessed measured height loss and fracture incidence in a prospective population study.Materials and Methods: Height was measured in participants in the Norfolk cohort of the European Prospective Investigation into Cancer (EPIC-Norfolk) between 1993 and 1997 and repeated between 1997 and 2000. Incident fractures to 2006 were ascertained by hospital record linkage.Results: In 14,921 men and women 42-82 yr of age, during a mean follow-up period of 7.1 yr, there were 390 fractures, including 122 hip fractures. Prior annual height loss in those who had an incident fracture (1.8 +/- 0.3 [SD] mm) was significantly greater than other participants (0.9 +/- 0.2 mm; p < 0.001). Participants with annual height loss >0.5 cm had an age- and sex-adjusted hazard ratio of any fracture of 1.76 (95% CI, 1.16-2.67) and of hip fracture of 2.08 (95% CI, 1.07-4.05) compared with those with no height loss. Each 1 cm/yr height loss was associated with a hazard ratio of 1.86 (95% CI, 1.28-2.72) for all fractures and 2.24 (95% CI, 1.23-4.09) for hip fracture after adjustment for age, sex, past history of fracture, smoking, body mass index, alcohol intake, and heel ultrasound measures. Annual height loss of 1 cm was comparable to having a past history of fracture and equivalent to being similar to 14 yr older in chronological age in terms of the magnitude of relationship with fracture risk.Conclusions: Middle-aged and older men and women with annual height loss >0.5 cut are at increased risk of hip and any fracture. Serial height measurements can contribute to fracture risk prediction.