Vocal cord inflammatory myofibroblastic tumor with mucoid deposits harboring TIMP3-ALK fusion: A potential diagnostic pitfall.
Vocal cord inflammatory myofibroblastic tumor with mucoid deposits harboring TIMP3-ALK fusion: A potential diagnostic pitfall.
复制标题
声带炎性肌纤维母细胞肿瘤，伴有含有 TIMP3-ALK 融合的粘液沉积物：一个潜在的诊断陷阱。
DOI：
10.1111/pin.12796
复制
发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Michal M.
中科院分区：
文献类型：
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作者：
Yorita K;Togashi Y;Nakagawa H;Miyazaki K;Sakata S;Baba S;Takeuchi K;Hayashi Y;Murakami I;Kuroda N;Oda Y;Kohashi K;Yamada Y;Kiyozawa D;Michal M;Michal M.
炎症性肌纤维母细胞瘤(IMTS)主要影响儿童和年轻人，通常发生在肠系膜、大网膜、腹膜后、骨盆和腹部软组织。1肌间质瘤的组织学特征为肌纤维母细胞和成纤维细胞梭形细胞，伴有含有浆细胞和淋巴细胞的炎性浸润物。约50%-70%的间变性淋巴瘤激酶(ALK)基因在染色体2p23上发生克隆性重排。1喉IMT是罕见的；截至2015年，大约有47例喉IMTS被描述，2只有5例ALK重排的喉IMT。2、3喉部IMT因切除不全而局部复发3，但未见转移病例。我们在这里介绍了声带IMT的临床病理、超微结构和遗传学特征。
Inflammatory myofibroblastic tumors (IMTs) primarily affect children and young adults and usually occur in the mesentery, omentum, retroperitoneum, pelvis, and abdominal soft tissue. 1 IMT is histologically characterized by myofibroblastic and fibroblastic spindle cells accompanied by an inflammatory infiltrate containing plasma cells and lymphocytes. Approximately 50%–70% of IMTs exhibit clonal rearrangements of the anaplastic lymphoma kinase (ALK) gene on chromosome 2p23. 1 Laryngeal IMTs are rare; approximately 47 cases of laryngeal IMTs have been described as of 2015, 2 with only five cases of ALK‐rearranged laryngeal IMTs. 2, 3 Local recurrence of laryngeal IMT due to incomplete resection has been observed3; however, metastasis has not been documented. We present here the clinicopathological, ultrastructural, and genetic features of a vocal cord IMT.