Organizational and Activational Effects of Testosterone on Masculinization of Female Physiological and Behavioral Stress Responses
Organizational and Activational Effects of Testosterone on Masculinization of Female Physiological and Behavioral Stress Responses
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DOI：
10.1210/en.2008-0433
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发表时间：
2008-12-01
期刊：
影响因子：
4.8
通讯作者：
Bale, Tracy L.
中科院分区：
文献类型：
--
作者：
Goel, Nirupa;Bale, Tracy L.
情感障碍在女性中的患病率是男性的两倍。焦虑和抑郁的发作发生在不同的年龄，这可能与大脑更容易受到荷尔蒙和外源性影响的关键发育时期相对应。由于紧张的生活事件可促使疾病发作，因此女性对压力更敏感的发展可能导致她们的脆弱性增加。男性在发育早期和青春期之后的性腺激素暴露在两性二态脑的形成中起着重要作用，可能导致应激反应的性别差异。因此，我们在小鼠身上研究了出生后施用丙酸睾酮（TP）的组织效应和青春期开始施用的TP对成年雌性生理和行为应激反应的激活效应。虽然TP在女性中的激活作用改善了下丘脑-垂体-肾上腺轴应激反应的性别差异，但出生后TP没有影响。同样，在没有产后TP的情况下，激活TP使完整雌性在悬尾试验中较高的静止时间变得迟钝。而在类焦虑行为的埋弹测试中，组织TP和激活TP分别导致埋弹行为的增加。这些结果表明，TP对降低啮齿动物的生理和行为应激反应有明显的作用，并提示这些反应的性别差异可能部分归因于雌性缺乏睾酮。（内分泌学49:6399-6405,2008）
The prevalence of affective disorders is two times greater in women than in men. The onset of anxiety and depression occurs at different ages that may correspond to key developmental periods when the brain is more vulnerable to hormonal and exogenous influences. Because stressful life events can precipitate disease onset, the development of greater stress sensitivity in females may contribute to their increased vulnerability. Gonadal hormone exposure in males during early development and again from puberty onward plays a prominent role in sexually dimorphic brain formation, possibly contributing to sex differences in stress responsivity. Therefore, organizational effects of testosterone propionate (TP) administered postnatally and activational effects of TP administered beginning at puberty on adult female physiological and behavioral stress responses were examined in mice. Although the activational effects of TP in females ameliorated the sex difference in the hypothalamic-pituitary-adrenal axis stress response, there was no effect of postnatal TP. Similarly, higher immobile time in intact females in the tail suspension test was blunted by activational TP in the absence of postnatal TP. However, in the marble-burying test of anxiety-like behaviors, organizational and activational TP independently resulted in increased burying behaviors. These results show that TP administration has distinct effects on reducing physiological and behavioral stress responsivity in rodent models and suggest that sex differences in these responses may partially result from the absence of testosterone in females. (Endocrinology 149: 6399-6405, 2008)