Combined effects of lactotripeptide and aerobic exercise on cognitive function and cerebral oxygenation in middle-aged and older adults
Combined effects of lactotripeptide and aerobic exercise on cognitive function and cerebral oxygenation in middle-aged and older adults
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DOI：
10.1093/ajcn/nqy235
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发表时间：
2019-02-01
影响因子：
7.1
通讯作者：
Maeda, Seiji
中科院分区：
文献类型：
--
作者：
Hamasaki, Ai;Akazawa, Nobuhiko;Maeda, Seiji
背景：脑卒中相关的认知功能和脑灌注下降会增加痴呆的风险。虽然营养和运动可能有效地减少认知能力下降，但乳三肽（LTP）对脑氧合和血流动力学的影响仍不清楚。目的：本研究的目的是调查在有或没有运动干预的中老年人中，摄入LTP对脑氧合、认知功能和血管功能的影响。方法：我们招募了两组不同的参与者，一组有运动干预，另一组没有运动干预。然后将每组随机分配到安慰剂组和LTP组。参与者每天服用安慰剂或LTP。运动组进行有氧运动4-6 d/wk。之前和之后的8周的干预，我们测量了氧合血红蛋白（oxy-Hb）浓度（oxy-Hb变化）在前额叶皮层Stroop任务（主要结果），Stroop干扰时间，和颈动脉β-刚度（两个次要outcomes）。在运动和非运动条件下，LTP组前额叶皮层氧合血红蛋白信号的变化均大于安慰剂组（P < 0.05）。此外，左前额叶皮质氧合血红蛋白变化的改善幅度与Stroop干扰（r =-0.39，P < 0.05）和颈动脉β-硬度（r=-0.41，P < 0.05）相关。结论：8周LTP摄入增加了中老年人前额叶皮质区域的脑氧合，无论是否运动。干预引起的脑神经激活的改善与认知和血管功能有关。本试验在www.umin.ac.jp上注册为UMIN 000022313。
Background: Age-related declines in cognitive function and cerebral perfusion increase the risk of dementia. Although nutrition and exercise may be effective in reducing cognitive decline, the effect of lactotripeptide (LTP) on cerebral oxygenation and hemodynamics remains unclear.Objectives: The aim of this study was to investigate the effects of LTP ingestion on cerebral oxygenation, cognitive function, and vascular function in middle-aged and older adults with or without an exercise intervention.Methods: We recruited 2 separate groups of participants, one with and one without an exercise intervention. Each group was then randomly assigned into a placebo group and an LTP group. The participants ingested a placebo or LTP every day. The exercise group performed aerobic exercises 4-6 d/wk. Before and after the 8-wk intervention, we measured oxygenated hemoglobin (oxy-Hb) concentration (oxy-Hb change) in the prefrontal cortex during the Stroop task (primary outcome), Stroop interference time, and carotid artery beta-stiffness (both secondary outcomes).Results: Sixty-four participants completed the study. Changes in oxy-Hb signal in the prefrontal cortex were greater in the LTP group than in the placebo group under both the exercise and nonexercise conditions (P < 0.05). In addition, the magnitude of improvement in the oxy-Hb change in the left prefrontal cortex was correlated with Stroop interference (r = -0.39, P < 0.05) and carotid beta-stiffness (r=-0.41, P < 0.05).Conclusions: An 8-wk intake of LTP increased cerebral oxygenation in the prefrontal cortex region in middle-aged and older adults, with and without exercise. The intervention-induced improvements in brain neural activation were associated with cognitive and vascular function. This trial was registered at www.umin.ac.jp as UMIN000022313.