Pharmacotherapy for recovery of function after brain injury.
Pharmacotherapy for recovery of function after brain injury.
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发表时间：
1987
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通讯作者：
D. M. Feeney;R. Sutton
中科院分区：
文献类型：
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作者：
D. M. Feeney;R. Sutton
最近相当多的注意力集中在促进脑损伤后功能恢复的药物疗法的开发上。本文回顾了两个领域的动物和人体实验，这两个领域似乎在不久的将来对促进康复具有相当大的临床适用性：神经递质系统的药物操纵和神经节苷脂的管理。由于脑损伤后最重要的问题是恢复失去的行为能力，因此这是本次综述的中心主题。这些药物作用的可能机制仅针对已证明对行为恢复有益或有害的治疗进行讨论。还试图指出可能的共同机制和各种治疗的临床潜力；提出了未来的研究方向。
Considerable attention has recently been focused on the development of pharmacotherapies for promotion of recovery of function after brain injury. This article reviews both animal and human experimentation in two areas which appear to have considerable clinical applicability in the very near future for promoting recovery: drug manipulation of neurotransmitter systems and administration of gangliosides. Since the most important problem after brain injury is restoration of lost behavioral capabilities, this is the central theme of this review. The possible mechanisms of the effects of these pharmacological agents are only discussed for treatments with demonstrated beneficial or harmful effects on behavioral recovery. An attempt is also made to indicate possible common mechanisms and the clinical potential of the various treatments; future directions for research are suggested.