Clinical factors associated with bacterial translocation in Japanese patients with type 2 diabetes: A retrospective study
Clinical factors associated with bacterial translocation in Japanese patients with type 2 diabetes: A retrospective study
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日本 2 型糖尿病患者与细菌易位相关的临床因素：一项回顾性研究
DOI：
10.1371/journal.pone.0222598
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发表时间：
2019
期刊：
影响因子：
3.7
通讯作者：
H. Watada
中科院分区：
文献类型：
--
作者：
Shoko Tamaki;A. Kanazawa;Junko Sato;Y. Tamura;T. Asahara;Takuya Takahashi;S. Matsumoto;Y. Yamashiro;H. Watada
目的探讨日本2型糖尿病（T2 DM）患者细菌易位的相关临床因素。方法回顾性分析118例2型糖尿病患者的临床资料，分析细菌移位相关的临床指标（菌血症检测）和血浆脂多糖结合蛋白（LBP）水平，后者被认为反映了内毒素血症引起的炎症反应。结果菌血症组与非菌血症组LBP水平无显著性差异。无临床因素与菌血症的检出显著相关。另一方面，血浆LBP水平与HbA 1c显著相关（r = 0.312），空腹血糖（r = 0.279），空腹C肽（r = 0.265），体重指数（r = 0.371）、高密度脂蛋白胆固醇（r = -0.241）和炎症标志物（高敏C反应蛋白，r = 0.543;白细胞介素-6，r = 0.456）。多元回归分析确定体重指数、糖化血红蛋白、高敏C反应蛋白和白细胞介素6是血浆LBP水平的独立决定因素。结论菌血症患者与非菌血症患者血浆LBP水平相似。虽然菌血症和LBP理论上都与细菌移位相关，但菌血症的检测与T2 DM中的LBP水平无关。
Objective To explore clinical factors associated with bacterial translocation in Japanese patients with type 2 diabetes mellitus (T2DM). Methods The data of 118 patients with T2DM were obtained from two previous clinical studies, and were retrospectively analyzed regarding the clinical parameters associated with bacterial translocation defined as detection of bacteremia and levels of plasma lipopolysaccharide binding protein (LBP), the latter of which is thought to reflect inflammation caused by endotoxemia. Results LBP level was not significantly different between patients with and without bacteremia. No clinical factors were significantly correlated with the detection of bacteremia. On the other hand, plasma LBP level was significantly correlated with HbA1c (r = 0.312), fasting blood glucose (r = 0.279), fasting C-peptide (r = 0.265), body mass index (r = 0.371), high-density lipoprotein cholesterol (r = -0.241), and inflammatory markers (high-sensitivity C-reactive protein, r = 0.543; and interleukin-6, r = 0.456). Multiple regression analysis identified body mass index, HbA1c, high-sensitivity C-reactive protein, and interleukin-6 as independent determinants of plasma LBP level. Conclusion The plasma LBP level was similar in patients with and without bacteremia. While both bacteremia and LBP are theoretically associated with bacterial translocation, the detection of bacteremia was not associated with LBP level in T2DM.