Neuronal diversity in the somatosensory system: bridging the gap between cell type and function
Neuronal diversity in the somatosensory system: bridging the gap between cell type and function
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DOI：
10.1016/j.conb.2019.03.002
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发表时间：
2019-06-01
影响因子：
5.7
通讯作者：
Goulding, Martyn
中科院分区：
文献类型：
--
作者：
Gatto, Graziana;Smith, Kelly Megan;Goulding, Martyn
最近一系列对小鼠的遗传学研究提供了关键的见解，即躯体感觉系统如何在细胞水平上组织编码瘙痒，疼痛，温度和触觉。这些研究在很大程度上基于这样的想法：功能细胞类型可以通过其独特的发育起源和基因表达谱来识别。然而，在何种程度上基因表达谱可以与功能细胞类型和电路组织仍然是一个悬而未决的问题。在这篇综述中，我们专注于表征感觉传入和背角神经元细胞类型的最新进展，处理皮肤体感信息和正在进行的电路研究，开始弥合细胞类型和功能之间的鸿沟。
A recent flurry of genetic studies in mice have provided key insights into how the somatosensory system is organized at a cellular level to encode itch, pain, temperature, and touch. These studies are largely predicated on the idea that functional cell types can be identified by their unique developmental provenance and gene expression profile. However, the extent to which gene expression profiles can be correlated with functional cell types and circuit organization remains an open question. In this review, we focus on recent progress in characterizing the sensory afferent and dorsal horn neuron cell types that process cutaneous somatosensory information and ongoing circuit studies that are beginning to bridge the divide between cell type and function.