Recent progress in understanding the phenotype and function of intestinal dendritic cells and macrophages.
Recent progress in understanding the phenotype and function of intestinal dendritic cells and macrophages.
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DOI：
10.1038/mi.2008.61
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发表时间：
2008-11
影响因子：
8
通讯作者：
Kelsall B
中科院分区：
文献类型：
--
作者：
Kelsall B
必须严格控制粘液免疫应答，特别是在肠中。作为单核吞噬细胞家族的成员，树突状细胞和巨噬细胞在肠组织中有很好的代表性，并且已经发展出独特的功能小生境。本文将重点介绍最近的研究结果抗原的摄取和处理在肠道中，以及在T和B细胞上的印记归巢受体的DC的作用，伊加B细胞反应的诱导，和调节性T细胞的分化（T细胞）。它还将解决肠道巨噬细胞的独特表型，并简要介绍了这些细胞类型之间的关系。
Mucosal immune responses must be tightly controlled, particularly in the intestine, As members of the mononuclear phagocyte family, dendritic cells and macrophages, are well represented in intestinal tissues, and have developed unique functional niches. This review will focus on recent findings on antigen uptake and processing in the intestine, and the role of DCs in the imprinting homing receptors on T and B cells, the induction of IgA B cell responses, and the differentiation of regulatory T cells (Tregs). It will also address the unique phenotype of intestinal macrophages and briefly what is known regarding the relationships between these cell types.