Estrogen decreases corpus striatal neurotoxicity in response to 6-hydroxydopamine
Estrogen decreases corpus striatal neurotoxicity in response to 6-hydroxydopamine
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DOI：
10.1016/s0006-8993(97)00630-6
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发表时间：
1997-09-05
期刊：
影响因子：
2.9
通讯作者：
Dluzen, D
中科院分区：
文献类型：
--
作者：
Dluzen, D
去卵巢大鼠用雌二醇丸处理或不用雌二醇丸处理后，单侧纹状体内注射6-羟基多巴胺(6-OHDA)。通过测定黑质纹状体多巴胺和二羟基苯乙酸(DOPAC)的浓度，测定了6-OHDA损毁侧和非损毁侧黑质纹状体多巴胺能功能的各种参数。雌激素处理的大鼠纹状体中的多巴胺浓度显著高于非雌激素处理的大鼠。雌激素组和非雌激素组大鼠的非损毁侧纹状体多巴胺浓度没有差异。与多巴胺相比，雌激素和非雌激素处理的大鼠在6-OHDA损毁侧的DOPAC浓度没有差异。在非雌激素治疗的大鼠中，纹状体非损毁侧的DOPAC浓度显著增加。这些结果表明，雌激素显著减少了由神经毒素6-OHDA引起的纹状体多巴胺的耗竭。DOPAC测定的数据表明，雌激素的这种能力可能是通过作用于纹状体多巴胺能神经元的摄取过程而发挥的。这些发现表明，雌激素可能是一种重要的调节因子，能够减轻纹状体内的变性，从而起到黑质纹状体多巴胺能系统的神经保护作用。(C)1997年爱思唯尔科学公司。
Ovariectomized rats treated or not with an estradiol pellet were subjected to an unilateral intrastriatal infusion of 6-hydroxydopamine (6-OHDA). Various parameters of nigrostriatal dopaminergic function as derived from measurements of dopamine and dihydroxyphenylacetic acid (DOPAC) concentrations were determined from the 6-OHDA lesioned and non-lesioned sides of the corpus striatum in these animals. Dopamine concentrations within the 6-OHDA lesioned striatum of estrogen-treated rats were significantly greater than non-estrogen-treated rats. There were no differences in striatal dopamine concentrations between estrogen-versus non-estrogen-treated rats on their non-lesioned side. In contrast to that of dopamine, no differences in DOPAC concentrations between estrogen and non-estrogen-treated rats were obtained within the 6-OHDA-lesioned side. The DOPAC concentrations on the non-lesioned side of the striatum were significantly greater in the non-estrogen-treated rats. These results demonstrate that estrogen significantly diminishes the depletion of striatal dopamine resulting from the neurotoxin 6-OHDA. The data obtained from the DOPAC determinations imply that this capacity of estrogen may be exerted through actions upon uptake processes of striatal dopaminergic neurons. Such findings suggest that estrogen may function as an important modulatory factor capable of attenuating degeneration within the corpus striatum, and in this way serve as a neuroprotectant of the nigrostriatal dopaminergic system. (C) 1997 Elsevier Science B.V.