Neural basis of pantomiming the use of visually presented objects
Neural basis of pantomiming the use of visually presented objects
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DOI：
10.1016/j.neuroimage.2003.11.017
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发表时间：
2004-04-01
期刊：
影响因子：
5.7
通讯作者：
Fink, GR
中科院分区：
文献类型：
--
作者：
Rumiati, RI;Weiss, PH;Fink, GR
对失用症患者的神经心理学研究强烈暗示了熟练使用物体的左半球基础，然而，其神经机制仍有待阐明。因此，我们在14名健康的人类志愿者中进行了PET研究，目的是分离物体触发器到熟练动作的感觉运动转换的神经机制。我们采用了析因设计，两个因素（响应：命名，哑剧;和触发：动作，对象）和四个条件（IA：模仿所观察到的哑剧; 10：哑剧使用所示的对象; NA：命名所观察到的哑剧; NO：命名所示的对象）。因此，设计的主要目的是调查的相互作用[即（OI-IA）-（NO-NA）]，这使得增加的神经活动的评估特定的对象触发器到熟练的动作的感觉运动转换。结果（P < 0.05，校正）表明，产生由物体（控制知觉，运动，语义和词汇效应）触发的广泛的熟练动作激活了左下顶叶皮层。这些数据提供了一个解释，为什么包括左顶叶皮质病变的患者患有概念性失用症的评估受损的对象使用和pontomining视觉呈现的对象。(C)2004爱思唯尔公司All rights reserved.
Neuropsychological studies of patients suffering from apraxia strongly imply a left hemisphere basis for skilful object use, the neural mechanisms of which, however, remain to be elucidated. We therefore carried out a PET study in 14 healthy human volunteers with the aim to isolate the neural mechanisms underlying the sensorimotor transformation of object-triggers into skilled actions. We employed a factorial design with two factors (RESPONSE: naming, pantomiming; and TRIGGER: actions, objects) and four conditions (IA: imitating the observed pantomime; 10: pantomiming the use of the object shown; NA: naming the observed pantomime; NO: naming the object shown). The design thus mainly aims at investigating the interaction [i.e. (OI-IA)-(NO-NA)] which allows the assessment of increased neural activity specific to the sensorimotor transformation of object-triggers into skilled actions. The results (P < 0.05, corrected) showed that producing a wide range of skilled actions triggered by objects (controlled for perceptual, motor, semantic, and lexical effects) activated left inferior parietal cortex. The data provide an explanation for why patients with lesions including left parietal cortex suffer from ideational apraxia as assessed by impaired object use and pontomining to visually presented objects. (C) 2004 Elsevier Inc. All rights reserved.