Does Early Childhood Vaccination Protect Against COVID-19?
Does Early Childhood Vaccination Protect Against COVID-19?
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DOI：
10.3389/fmolb.2020.00120
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发表时间：
2020-06-05
影响因子：
5
通讯作者：
Kodzius, Rimantas
中科院分区：
文献类型：
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作者：
Sidiq, Karzan R.;Sabir, Dana Khdr;Kodzius, Rimantas
2019冠状病毒病（COVID-19）是由SARS-冠状病毒-2（SARS-CoV-2）引起的持续大流行病，其靶向人类呼吸系统。公布的数据显示，儿童与成人不同，不易感染这种疾病。本文旨在了解为什么儿童在住院的COVID-19患者中占少数。在这里，我们假设麻疹，腮腺炎和风疹（MMR）疫苗可以提供针对包括COVID-19在内的许多疾病的广泛中和抗体。我们的假设是基于麻疹病毒融合（F1）糖蛋白（PDB：5YXW_B）和风疹病毒包膜（E1）糖蛋白（PDB：4ADG_A）的SARS-CoV-2刺突（S）糖蛋白（PDB：6VSB）之间的30个氨基酸序列同源性。同源区的计算分析检测到麻疹和风疹的抗原表位的序列。因此，我们认为通过MMR疫苗接种产生的体液免疫也为儿童提供了有利的COVID-19保护，但需要进行实验分析。
The coronavirus disease 2019 (COVID-19) is an on-going pandemic caused by the SARS-coronavirus-2 (SARS-CoV-2) which targets the respiratory system of humans. The published data show that children, unlike adults, are less susceptible to contracting the disease. This article aims at understanding why children constitute a minor group among hospitalized COVID-19 patients. Here, we hypothesize that the measles, mumps, and rubella (MMR) vaccine could provide a broad neutralizing antibody against numbers of diseases, including COVID-19. Our hypothesis is based on the 30 amino acid sequence homology between the SARS-CoV-2 Spike (S) glycoprotein (PDB: 6VSB) of both the measles virus fusion (F1) glycoprotein (PDB: 5YXW_B) and the rubella virus envelope (E1) glycoprotein (PDB: 4ADG_A). Computational analysis of the homologous region detected the sequence as antigenic epitopes in both measles and rubella. Therefore, we believe that humoral immunity, created through the MMR vaccination, provides children with advantageous protection against COVID-19 as well, however, an experimental analysis is required.