Ultrasmall Au and Ag Nanoclusters for Biomedical Applications: A Review.
Ultrasmall Au and Ag Nanoclusters for Biomedical Applications: A Review.
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用于生物医学应用的超小型金和银纳米团簇：综述
DOI：
10.3389/fbioe.2020.01019
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发表时间：
2020
影响因子：
5.7
通讯作者：
Tang Z
中科院分区：
文献类型：
--
作者：
Tang J;Shi H;Ma G;Luo L;Tang Z
贵金属（如金、银、铂、钯及其合金）纳米团簇（NCs）在纳米科学和纳米技术领域已成为一种新型的功能纳米材料。由于其独特的性质，如超小尺寸、增强的光致发光、低毒性和优异的生物相容性，贵金属纳米材料，特别是金和银纳米材料，在生物医学领域有着广泛的应用。本文综述了近年来利用超小金和银纳米细胞在生物医学上的应用，重点介绍了生物成像和生物传感、抗微生物应用、肿瘤靶向和癌症治疗等方面的研究进展。最后简要讨论了Au和Ag纳米材料在生物医学应用方面面临的共同挑战和具体挑战，以及未来的发展方向。
Noble metal (e.g., Au, Ag, Pt, Pd, and their alloys) nanoclusters (NCs) have emerged as a new type of functional nanomaterial in nanoscience and nanotechnology. Owing to their unique properties, such as their ultrasmall dimension, enhanced photoluminescence, low toxicity, and excellent biocompatibility, noble metal NCs—especially Au and Ag NCs—have found various applications in biomedical regimes. This review summarizes the recent advances made in employing ultrasmall Au and Ag NCs for biomedical applications, with particular emphasis on bioimaging and biosensing, anti-microbial applications, and tumor targeting and cancer treatment. Challenges, including the shared and specific challenges for Au and Ag NC toward biomedical applications, and future directions are briefly discussed at the end.