Other therapies for BPH patients: desmopressin, anti-cholinergic, anti-inflammatory drugs, and botulinum toxin
Other therapies for BPH patients: desmopressin, anti-cholinergic, anti-inflammatory drugs, and botulinum toxin
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DOI：
10.1007/s00345-006-0095-x
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发表时间：
2006-09-01
影响因子：
3.4
通讯作者：
de la Taille, Alexandre
中科院分区：
文献类型：
--
作者：
Azzouzi, Abdel-Rahmene;Fourmarier, Marc;de la Taille, Alexandre
良性前列腺增生（BPH）的常规治疗包括α -受体阻滞剂、5- α还原酶抑制剂和植物治疗药物，可显著改善下尿路症状（LUTS）。然而，一些患者对治疗没有反应或有副作用。文献中描述的其他治疗方法是可能的，以减轻LUTS。抗胆碱能药物似乎对刺激性症状有效，即使它们在有前列腺增生时被认为是禁忌的。抗利尿激素可用于治疗利尿逆转所致的夜尿症。炎症是BPH潜在机制的一部分，因此抗炎药物的作用必须修订。最终，肉毒杆菌毒素越来越多地用于神经性膀胱患者，也可能在LUTS中发挥作用。如果对这些不同治疗方法的临床研究证实了初步结果，负责指导方针的学会将不得不通过添加这些新的治疗方法来更新决策树。
The usual treatments of benign prostate hyperplasia (BPH) including the alpha-blockers, the inhibitors of the 5-alpha reductase and the phytotherapy drugs allow significant improvements of the lower urinary tracts symptoms (LUTS). However, some patients are not responders or have side effects due to the treatments. Other therapeutic approaches described in the literature are possible in order to alleviate the LUTS. The anti-cholinergic drugs seem to be efficient against the irritating symptoms even if they are supposed to be contra-indicated when there is BPH. Anti-diuretic hormone could be useful to treat nocturia due to diuresis reversal. Inflammation is a part of the underlying mechanisms of BPH and as such the role of the anti-inflammatory drugs has to be revised. Eventually, botulinum toxin is more and more used for patients with neurological bladder and could also have a role in LUTS. If the coming clinical studies on those different treatments confirm the preliminary results, the learning societies in charge of the guidelines would have to update the decision trees by adding these new therapeutic approaches.