DISEASE ECOLOGY Ecological and evolutionary effects of fragmentation on infectious disease dynamics
DISEASE ECOLOGY Ecological and evolutionary effects of fragmentation on infectious disease dynamics
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DOI：
10.1126/science.1253621
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发表时间：
2014-06-13
期刊：
影响因子：
56.9
通讯作者：
Laine, Anna-Liisa
中科院分区：
文献类型：
--
作者：
Jousimo, Jussi;Tack, Ayco J. M.;Laine, Anna-Liisa
生态学理论预测，疾病发病率随着寄主网络密度的增加而增加，而进化理论则表明，寄主抵抗力也相应增加。为了检验生态和进化力量对寄主-病原物系统的联合作用，我们分析了植物(车前子)-真菌病原菌(植物)在4000多个寄主种群中长达12年的时空动态。集合种群水平的疾病流行率很低，每年病原体消失率很高，与频繁的(重新)定殖化相平衡。高度关联的寄主种群经历了比预期更少的病原体定植和更高的病原体消失率；实验室测试证实，这种现象是由于高度关联的寄主种群具有更高的抗病水平所致。
Ecological theory predicts that disease incidence increases with increasing density of host networks, yet evolutionary theory suggests that host resistance increases accordingly. To test the combined effects of ecological and evolutionary forces on host-pathogen systems, we analyzed the spatiotemporal dynamics of a plant (Plantago lanceolata)-fungal pathogen (Podosphaera plantaginis) relationship for 12 years in over 4000 host populations. Disease prevalence at the metapopulation level was low, with high annual pathogen extinction rates balanced by frequent (re-) colonizations. Highly connected host populations experienced less pathogen colonization and higher pathogen extinction rates than expected; a laboratory assay confirmed that this phenomenon was caused by higher levels of disease resistance in highly connected host populations.