Aversion-related circuitry in the cerebellum: responses to noxious heat and unpleasant images.
Aversion-related circuitry in the cerebellum: responses to noxious heat and unpleasant images.
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DOI：
10.1523/jneurosci.6709-10.2011
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发表时间：
2011-03-09
期刊：
影响因子：
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通讯作者：
Borsook D
中科院分区：
文献类型：
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作者：
Moulton EA;Elman I;Pendse G;Schmahmann J;Becerra L;Borsook D
小脑在急性和慢性疼痛状态下都被激活，但目前尚不清楚对厌恶性疼痛刺激的反应是否可以推广到其他厌恶性刺激。我们假设疼痛时小脑的激活反映了厌恶刺激的高水平编码。我们使用功能性磁共振成像（fMRI）比较了11名健康志愿者的小脑对应用于手部的有害热量（46°C）和被动观看从国际情感图像系统（IAPS）中选择的图像的反应。以有害热量和令人不快的图像（令人不快的与中性的）形式出现的厌恶刺激激活了小脑后部的重叠区域，特别是在第六小叶、第一小腿和第七小叶。令人愉快的图片（愉快的与中性的）与令人厌恶的刺激所观察到的激活模式不同。小脑区域显示与热痛和不愉快的图像观看功能重叠，与边缘系统结构（包括下丘脑前部、亚属前扣带皮层和海马旁回）测量的fMRI信号显著负相关。热特异性功能连通性在许多区域被检测到，包括初级运动皮层、次级体感皮层、前脑岛和导水管周围灰质。小脑小叶对有害热量的反应和对不愉快图像的被动观看之间的重叠表明，小脑可能包含编码广义厌恶加工的特定区域。不同的皮层网络表明，小脑的有害热诱发反应可以分为感觉运动网络和情绪网络。
The cerebellum is reliably activated during both acute and chronic pain conditions, but it is unclear if the response to aversive painful stimuli can be generalized to other aversive stimuli. We hypothesized that cerebellar activation during pain reflects higher-level encoding of aversive stimuli. We used functional magnetic resonance imaging (fMRI) to compare cerebellar responses in 11 healthy volunteers to noxious heat (46°C) applied to the hand and to the passive viewing of images selected from the International Affective Picture System (IAPS). Aversive stimuli in the form of noxious heat and unpleasant pictures (unpleasant vs. neutral) activated overlapping areas in the posterior cerebellum, specifically in hemispheric lobule VI, Crus I, and VIIb. Pleasant pictures (pleasant vs. neutral) did not share the same pattern of activation as observed with the aversive stimuli. Cerebellar areas that showed functional overlap with both heat pain and unpleasant picture viewing were significantly inversely correlated with fMRI signals measured in limbic system structures, including the anterior hypothalamus, subgenual anterior cingulate cortex, and the parahippocampal gyrus. Heat specific functional connectivity was detected in many regions including primary motor cortex, secondary somatosensory cortex, anterior insula, and the periaqueductal gray. The overlap between cerebellar lobuli reactive to noxious heat and passive viewing of unpleasant images suggest that the cerebellum may contain specific regions involved in encoding generalized aversive processing. The separate cortical networks suggest that noxious heat evoked responses in the cerebellum can be divided into sensorimotor and emotional networks.