PARTICIPATION OF THE DORSAL HIPPOCAMPUS IN THE GLUCOCORTICOID FEEDBACK EFFECT ON ADRENOCORTICAL ACTIVITY
PARTICIPATION OF THE DORSAL HIPPOCAMPUS IN THE GLUCOCORTICOID FEEDBACK EFFECT ON ADRENOCORTICAL ACTIVITY
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DOI：
10.1159/000122974
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发表时间：
1980-01-01
影响因子：
4.1
通讯作者：
CONFORTI, N
中科院分区：
文献类型：
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作者：
FELDMAN, S;CONFORTI, N
在正常大鼠和双侧海马伞背侧或腹侧切除动物模型上，研究了全身应用地塞米松对基础血浆皮质酮水平和肾上腺皮质对乙醚加皮肤切开应激反应的反馈作用。在腹侧海马区切除或海马伞切断的大鼠，反馈程度与正常大鼠相似。然而，在背侧海马区切除的动物中，地塞米松对基础和应激诱导的肾上腺皮质反应的抑制作用显著降低。这些结果与前人的观察结果相结合，表明地塞米松对大脑有影响，而背侧海马区参与了垂体-肾上腺功能的反馈调节。地塞米松可对脑垂体产生影响，其作用可能是地塞米松对脑垂体的作用加上缺乏海马区的传入。
The feedback effect of systemically administered dexamethasone on basal plasma corticosterone levels and on adrenocortical responses to ether plus skin incision stress were studied in intact rats and in animals with bilateral dorsal or ventral hippocampectomy of fimbria section. In rats with ventral hippocampectomy or fimbria section, the degree of the feedback was similar to that in intact rats. However, in animals with dorsal hippocampectomy, the inhibitory effect of dexamethasone on basal and stress-induced adrenocortical responses was significantly reduced. These results taken together with previous observations, that section of the dorsal fornix has a similar effect, suggest that dexamethasone exerts its influence on the brain and that the dorsal hippocampal formation participates in the feedback regulation of pituitary-adrenal function. Dexamethasone may exert its influence on the pituitary, and the effect observed may be summation of dexamethasone action on the pituitary plus lack of hippocampal input.