Taxol resistance
Taxol resistance
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DOI：
10.1159/000007306
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发表时间：
2000-09-01
期刊：
影响因子：
3.3
通讯作者：
Fellous, A
中科院分区：
文献类型：
--
作者：
Sangrajrang, S;Fellous, A
背景：近年来，紫杉醇在癌症治疗中受到广泛关注，并成功用于治疗多种肿瘤，包括乳腺癌、卵巢癌和肺癌。尽管在临床前和临床上取得了成功，但肿瘤对治疗药物产生获得性耐药的能力仍然是癌症治愈的主要障碍。更好地了解紫杉醇耐药的各种机制可能对癌症治疗策略的设计具有重要意义。方法：本综述总结了迄今为止有关紫杉醇的作用和耐药性发展的信息，特别关注微管的改变。结果与讨论：对紫杉醇的获得性抗性是多种适应的函数。尽管紫杉醇的细胞转运似乎是紫杉醇耐药的重要机制，但微管变化的转录改变和翻译后修饰可能与耐药机制有关。版权所有 (C) 2000 S. Karger AG，巴塞尔。
Background: Taxol has gained considerable attention in cancer therapy in recent years and is successfully used in treating a variety of tu mo rs, including those of the breast, ovary and lung. Despite its preclinical and clinical success, the ability of tumors to develop an acquired resistance to drugs used for treatment remains a major obstacle to cancer cure. A better understanding of the various mechanisms of Taxol resistance may have important implications for strategies designed for cancer treatment. Method: This review summarizes the information available to date concerning the effects of Taxol and the development of drug resistance, focusing particularly on alterations in microtubules. Results and Discussion: Acquired resistance to Taxol is a function of multiple adaptations. Although the cellular transport of Taxol appears to be an important mechanism of resistance to Taxol, altered transcription and posttranslational modification of microtubular changes may be involved in the mechanism of drug resistance. Copyright (C) 2000 S. Karger AG, Basel.