c-Fos immunoreactivity in selected brain regions of rats after heat exposure and pyrogen administration
c-Fos immunoreactivity in selected brain regions of rats after heat exposure and pyrogen administration
复制标题
DOI：
10.1016/j.brainres.2006.08.062
复制
发表时间：
2006-11-20
期刊：
影响因子：
2.9
通讯作者：
Laburn, Helen P.
中科院分区：
文献类型：
--
作者：
du Plessis, Irne;Mitchell, Duncan;Laburn, Helen P.
本研究测定了外源性热暴露、革兰氏阴性或阳性致热原诱导的大鼠高温后下丘脑核团、终板层血管器（OVLT）和躯体感觉皮质中c-Fos免疫反应性（Fos IR）的变化。热暴露或脂多糖（LPS）注射后，大鼠下丘脑温度调节核团的Fos-IR的幅度是相似的，尽管不同的起源hyperplasia。热诱导的体温过高与躯体感觉皮层中Fos-IR的增加有关。LPS，但不热暴露或注射杀死的金黄色葡萄球菌细胞激活OVLT神经元。因此，OVLT可能不是革兰氏阳性细菌发热的体液介质的入口。(c)2006 Elsevier B. V.保留所有权利。
We determined c-Fos immunoreactivity (Fos-IR) in selected hypothalamic nuclei, the organum vasculosum of the laminae terminals (OVLT) and somatosensory cortex of rats after hyperthermia induced by exogenous heat exposure, Gram-negative or Gram-positive pyrogen administration. The magnitude of Fos-IR was similar in thermoregulatory hypothalamic nuclei of rats after heat exposure or lipopolysaccharide (LPS) injection, despite the different origins of the hyperthermias. Heat-induced hyperthermia was associated with increased Fos-IR in the somatosensory cortex. LPS, but not heat exposure or injection of killed Staphylococcus aureus cells activated OVLT neurons. The OVLT may thus not be a port of entry for humoral mediators of Gram-positive bacterial fevers. (c) 2006 Elsevier B.V. All rights reserved.