Blueberry juice augments exercise-induced neuroprotection in a Parkinson's disease model through modulation of GDNF levels.
Blueberry juice augments exercise-induced neuroprotection in a Parkinson's disease model through modulation of GDNF levels.
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DOI：
10.1016/j.ibneur.2022.03.001
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发表时间：
2022-06
影响因子：
1.5
通讯作者：
Smith AD
中科院分区：
文献类型：
--
作者：
Castro SL;Tapias V;Gathagan R;Emes A;Brandon TE;Smith AD
锻炼和食用富含多酚的植物性食品是预防和治疗帕金森病 (PD) 的有吸引力的治疗方法。然而，很少有研究探讨结合这些治疗方式对帕金森病的神经保护功效。因此，我们研究了自愿跑步和饮用蓝莓汁 (BBJ) 相结合是否比单独治疗更能有效对抗 6-羟基多巴胺 (6-OHDA) 毒性。纹状体内 6-OHDA 前后跑步 4 周，可减少安非他明诱导的旋转行为和黑质多巴胺 (DA) 神经元的损失。单独食用 BBJ 没有改善作用，但与单独运动相结合时，行为缺陷和黑质纹状体 DA 神经变性的减少程度比单独运动更大。单独运动观察到的神经保护作用与纹状体胶质细胞衍生神经营养因子 (GDNF) 的增加相关，而运动和 BBJ 相结合则与黑质 GDNF 的增加相关。这些结果表明，多酚可能会增强运动的保护作用，并且 GDNF 表达的差异调节是单独运动与服用 BBJ 联合治疗所观察到的保护作用的基础。
Exercise and consumption of plant-based foods rich in polyphenols are attractive therapeutic approaches for the prevention and treatment of Parkinson’s disease (PD). Few studies, however, have examined the neuroprotective efficacy of combining these treatment modalities against PD. Therefore we investigated whether combining voluntary running and consumption of blueberry juice (BBJ) was more efficacious against 6-hydroxydopamine (6-OHDA) toxicity than either treatment alone. Four weeks of running before and after intrastriatal 6-OHDA reduced amphetamine-induced rotational behavior and loss of substantia nigra dopamine (DA) neurons. BBJ consumption alone had no ameliorative effects, but when combined with exercise, behavioral deficits and nigrostriatal DA neurodegeneration were reduced to a greater extent than exercise alone. The neuroprotection observed with exercise alone was associated with an increase in striatal glial cell-lined derived neurotrophic factor (GDNF), whereas combining exercise and BBJ was associated with an increase in nigral GDNF. These results suggest that polyphenols may potentiate the protective effects of exercise and that differential regulation of GDNF expression underlies protection observed with exercise alone versus combined treatment with consumption of BBJ.
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影响因子：
9.9
作者：
Gao, X.;Cassidy, A.;Ascherio, A.
通讯作者：
Ascherio, A.
影响因子：
3.7
作者：
Aguiar, Aderbal S., Jr.;Lopes, Samantha C.;Prediger, Rui D.
通讯作者：
Prediger, Rui D.
影响因子：
3.3
作者：
Churchill, M. J.;Pflibsen, L.;Meshul, C. K.
通讯作者：
Meshul, C. K.
DOI：
10.1249/mss.0000000000000310
发表时间：
2014-10-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Chang, Heng-Chih;Yang, Yea-Ru;Wang, Ray-Yau
通讯作者：
Wang, Ray-Yau
影响因子：
10.6
作者：
Guo, Shuhong;Yan, Jingqi;Zhao, Baolu
通讯作者：
Zhao, Baolu