Quality of life in 188 patients with myasthenia gravis in China
Quality of life in 188 patients with myasthenia gravis in China
复制标题
中国188例重症肌无力患者的生活质量
DOI：
10.3109/00207454.2015.1038712
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发表时间：
2016-01-01
影响因子：
2.2
通讯作者：
Li, Zhuyi
中科院分区：
文献类型：
--
作者：
Yang, Yongxiang;Zhang, Min;Li, Zhuyi
重症肌无力（Myasthenia gravis，MG）是一种慢性自身免疫性疾病，可使患者的运动功能下降，进而影响健康相关生活质量（health-related quality of life，HRQoL）。本研究的主要目的是评估可能影响MG患者HRQoL的因素。对188例重症肌无力患者进行横断面临床研究。采用美国重症肌无力基金会（MGFA）分级和定量重症肌无力（QMG）评分评估病情严重程度。使用医学结局调查36项简表健康调查（SF-36）估计HRQoL。采用汉密尔顿抑郁量表（HDRS）和汉密尔顿焦虑量表（HARS）评定抑郁和焦虑症状。影响MG患者HRQoL的因素包括年龄、文化程度、职业、胸腺状况、MG和全身型重症肌无力（GMG）的类型、病情严重程度、心理障碍等。高QMG和HARS评分是导致低PCS和低MCS的两个显著因素，而年龄是导致低PCS的一个显著因素。本研究结果可能对MG的临床治疗策略具有潜在的指导意义，从而提高MG患者的生活质量。除了治疗躯体症状外，还应关注焦虑、抑郁等心理症状。
Myasthenia gravis (MG) is a kind of chronic autoimmune disease which can weaken patients' motor function and, furthermore, produce negative impact on the health-related quality of life (HRQoL). The primary purpose of this research was to evaluate factors that might affect the HRQoL of MG patients. A cross-sectional clinical research was carried out including 188 successive patients with MG. Myasthenia Gravis Foundation of America (MGFA) classification and Quantitative Myasthenia Gravis (QMG) score were applied to assess the severity of the disease. The Medical Outcome Survey 36-Item Short-Form Health Survey (SF-36) was used to estimate the HRQoL. Hamilton Depression Rating Scale (HDRS) and Hamilton Anxiety Rating Scale (HARS) were utilized to measure the depression and anxiety symptom. Factors may influence the HRQoL of MG patients include age, educational level, occupation, the situation of the thymus, the type of MG and generalized myasthenia gravis (GMG), the severity of the disease and the psychological disorder. Higher QMG and HARS scores were two significant factors that can prognosticate lower Physical Composite Score (PCS) and Mental Composite Score (MCS), while older age was just a significant factor which has prognostic value for lower PCS. The results of this research may have a potential guiding significance for the clinical treatment strategy and improve the quality of life in patients with MG consequently. In addition to the treatment of physical symptoms, the psychological symptoms such as anxiety and depression should be concerned as well.