Nutrient intake and hypertensive disorders of pregnancy: Evidence from a large prospective cohort.
Nutrient intake and hypertensive disorders of pregnancy: Evidence from a large prospective cohort.
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DOI：
10.1067/mob.2001.111101
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发表时间：
2001-03
影响因子：
9.8
通讯作者：
C. Morris;S. Jacobson;R. Anand;M. Ewell;J. Hauth;L. Curet;P. Catalano;B. Sibai;R. Levine
中科院分区：
文献类型：
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作者：
C. Morris;S. Jacobson;R. Anand;M. Ewell;J. Hauth;L. Curet;P. Catalano;B. Sibai;R. Levine
本分析的目的是前瞻性地确定营养摄入对参加钙预防子痫前期研究的妇女子痫前期和妊娠相关高血压发病率的影响。研究设计：这是一项前瞻性观察队列研究，在一项随机临床试验中对妇女进行研究，包括在美国5个社区的大学医学中心和附属诊所和医院寻求产前护理的妇女。总共招募了4589名怀孕13至21周的未生育妇女。子痫前期和妊娠高血压是主要的结局指标。结果在4314例妊娠结局已知的妇女中，326例（7.6%）出现先兆子痫，747例（17.3%）出现妊娠相关高血压。正如先前报道的那样，在随机分配补钙组和安慰剂组之间，这些结果没有显著差异。采用logistic回归方法建立子痫前期和妊娠高血压的基线风险模型。在调整治疗和临床地点后，体重指数>26 kg/m(2)和种族与子痫前期风险增加显著相关。体重指数>或=35 kg/m(2)、种族和从不吸烟与妊娠高血压风险增加显著相关。在对基线风险进行调整后，分析的28种营养因素中没有一种与子痫前期或妊娠相关高血压有显著相关性。结论：在这项研究中，我们没有发现妊娠高血压疾病与所测量的23种营养素中的任何一种有显著关联的证据。
OBJECTIVE The objective of this analysis was to prospectively determine the effects of nutrient intakes on the incidences of preeclampsia and pregnancy-associated hypertension among women enrolled in the Calcium for Preeclampsia Prevention study. STUDY DESIGN This was a prospective observational cohort study of women in a randomized clinical trial that included women seeking prenatal care at university medical centers and affiliated clinics and hospitals in 5 US communities. A total of 4589 nulliparous women were recruited between 13 and 21 weeks' gestation. Preeclampsia and pregnancy-associated hypertension were the main outcome measures. RESULTS Preeclampsia was noted in 326 (7.6%) of the 4314 women with known pregnancy outcomes followed up until > or =20 weeks' gestation, and pregnancy-associated hypertension was noted in 747 (17.3%). As previously reported, there was no significant difference in these outcomes between cohorts randomly assigned to supplementation with calcium or placebo. By means of logistic regression a baseline risk model was constructed for preeclampsia and pregnancy-associated hypertension. After adjustment for treatment and clinical site, body mass index >26 kg/m(2) and race were significantly associated with an increased risk of preeclampsia. Body mass index > or =35 kg/m(2), race, and never smoking were significantly associated with an increased risk of pregnancy-associated hypertension. After adjustment for baseline risks, none of the 28 nutritional factors analyzed were significantly related to either preeclampsia or pregnancy-associated hypertension. CONCLUSION We found no evidence in this study for a significant association of hypertensive disorders of pregnancy with any of the 23 nutrients measured.