Recent advances in clinical practice challenges and opportunities in the management of obesity.
Recent advances in clinical practice challenges and opportunities in the management of obesity.
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DOI：
10.1136/gutjnl-2013-306235
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发表时间：
2014-04
期刊：
影响因子：
24.5
通讯作者：
Camilleri M
中科院分区：
文献类型：
--
作者：
Acosta A;Abu Dayyeh BK;Port JD;Camilleri M
尽管对肥胖、食物摄入、胃肠道和脂肪细胞相关激素、炎症介质、肠-脑轴和下丘脑神经系统在肥胖病理生理学中的作用的理解取得了进展，但不同治疗干预对这些病理生理学机制的影响仍存在争议。对于肥胖及其并发症，仍然没有低成本、安全、有效的治疗方法。目前，针对胃肠道的减肥手术方法在诱导体重减轻和解决肥胖相关合并症方面比非手术方法更有效。然而，目前的指南强调通过生活方式改变和药物治疗来实现缓慢减肥的非手术方法，这通常不会持续，并且可能与药物相关的副作用有关。这篇综述分析了目前治疗肥胖的中枢、外周或激素靶点，并提出了开发新的肥胖治疗方法的挑战和机遇。
Despite advances in understanding the roles of adiposity, food intake, gastrointestinal and adipocyte-related hormones, inflammatory mediators, the gut-brain axis, and the hypothalamic nervous system in the pathophysiology of obesity, the effects of different therapeutic interventions on those pathophysiological mechanisms are controversial. There are still no low cost, safe, effective treatments for obesity and its complications. Currently, bariatric surgical approaches targeting the gastrointestinal tract are more effective than non-surgical approaches in inducing weight reduction and resolving obesity-related comorbidities. However, current guidelines emphasize non-surgical approaches through life-style modification and medications to achieve slow weight loss, which is not usually sustained and may be associated with medication-related side effects. This review analyzes current central, peripheral, or hormonal targets to treat obesity, and addresses challenges and opportunities to develop novel approaches for obesity.
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影响因子：
29.4
作者：
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通讯作者：
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Abu Dayyeh, Barham K;Thompson, Christopher C
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