Enhanced integumental and ocular amelanosis following the termination of cyclosporine administration.
Enhanced integumental and ocular amelanosis following the termination of cyclosporine administration.
复制标题
环孢素给药终止后，外皮和眼部无黑变性增强。
DOI：
10.1111/1523-1747.ep12470453
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
SmythJr,JR
中科院分区：
文献类型：
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作者：
Pardue,SL;Fite,KV;Bengston,L;Lamont,SJ;Boyle3rd,ML;SmythJr,JR
Smyth迟发性无黑色素病鸡群表现出与人类白癜风相关的常见症状。免疫抑制化合物环孢素的管理，显着延迟发病的平均年龄和发病率的皮肤色素损失在这个突变系的白癜风鸡。相关的眼部病理学在处理的雏鸡中也不太严重。终止环孢霉素给药导致增强的皮肤和脉络膜无色素沉着，脉络膜炎症，脉络膜视网膜损伤超过未治疗的对照组中观察到的。这些结果表明，在治疗这种自发性自身免疫性疾病时停用环孢霉素可能会加重相关症状。
The Smyth delayed amelanotic line of chickens display symptoms commonly associated with human vitiligo. Administration of the immunosuppressive compound, cyclosporine, significantly delayed the mean age of onset and incidence of integumental pigment losses in this mutant line of vitiliginous chickens. Associated ocular pathology was also less severe in treated chicks. Termination of cyclosporine administration resulted in enhanced integumental and choroidal amelanosis, choroidal inflammation, and chorioretinal damage beyond that observed in nontreated controls. These results suggest that withdrawal of cyclosporine in treatment of this spontaneous autoimmune disease may exacerbate associated symptoms.