Genetic Engineering of Mesenchymal Stem Cells to Induce Their Migration and Survival.
Genetic Engineering of Mesenchymal Stem Cells to Induce Their Migration and Survival.
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DOI：
10.1155/2016/4956063
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发表时间：
2016
影响因子：
4.3
通讯作者：
Janowski M
中科院分区：
文献类型：
--
作者：
Nowakowski A;Walczak P;Lukomska B;Janowski M
间充质干细胞（MSCs）由于其相对容易获取以及具有广泛的自然分化能力或通过细胞工程诱导的分化能力，在再生医学中极具吸引力。然而，向病变组织的有效递送方法以及移植细胞的长期存活仍需改进。在此，我们综述了旨在增强间充质干细胞迁移能力以及通过调节促存活方法（包括预防衰老和凋亡）来延长其移植后存活的基因工程方法。我们重点介绍了一些探索这些关键点的最新实例，这些实例在基于细胞的治疗中具有重要意义。
Mesenchymal stem cells (MSCs) are very attractive for regenerative medicine due to their relatively easy derivation and broad range of differentiation capabilities, either naturally or induced through cell engineering. However, efficient methods of delivery to diseased tissues and the long-term survival of grafted cells still need improvement. Here, we review genetic engineering approaches designed to enhance the migratory capacities of MSCs, as well as extend their survival after transplantation by the modulation of prosurvival approaches, including prevention of senescence and apoptosis. We highlight some of the latest examples that explore these pivotal points, which have great relevance in cell-based therapies.