Maternal serum level of the DDT metabolite DDE in relation to fetal loss in previous pregnancies
Maternal serum level of the DDT metabolite DDE in relation to fetal loss in previous pregnancies
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DOI：
10.1016/s0013-9351(03)00108-7
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发表时间：
2005-02-01
影响因子：
8.3
通讯作者：
Brock, JW
中科院分区：
文献类型：
--
作者：
Longnecker, MP;Klebanoff, MA;Brock, JW
1，1，1-三氯-2，2-双（对氯苯基）乙烷（滴滴涕）在大约25个国家继续使用。这种使用的部分理由是认为它对人类健康没有不利影响。然而，关于滴滴涕对生殖产生不利影响的证据越来越多，但还需要更多的数据。参加围产期合作计划（美国，1959-1965年）的孕妇被问及她们以前的怀孕史;抽取血液样本并冷冻血清。在1997-1999年，对1717名有过妊娠史的妇女的血清进行了滴滴涕主要分解产物1，1-二氯-2，2-二（对氯苯基）乙烯（DDE）的分析。在逻辑回归模型中，检查了与DDE水平相关的先前胎儿丢失的几率。与DDE水平< 15 mug/L的妇女相比，根据DDE类别调整的胎儿丢失的比值比如下：15-29 mug/L，1.1; 30-44 mug/L，1.4; 45-59 mug/L，1.6; 60 + mug/L，1.2。每增加60 μ g/L的校正比值比为1.4（95%置信区间1.1-1.6）。该结果与DDE对胎儿丢失的不良影响一致，但由于先前终止于胎儿丢失的妊娠降低血清DDE水平的可能性低于足月妊娠，因此尚不确定。爱思唯尔公司出版
Use of 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) continues in about 25 countries. This use has been justified partly by the belief that it has no adverse consequences on human health. Evidence has been increasing, however, for adverse reproductive effects of DDT, but additional data are needed. Pregnant women who enrolled in the Collaborative Perinatal Project (United States, 1959-1965) were asked about their previous pregnancy history; blood samples were drawn and the serum frozen. In 1997-1999, the sera of 1717 of these women who had previous pregnancies were analyzed for 1,1-dichloro-2,2-bis(p-chloropbenyl)ethylene (DDE), the major breakdown product of DDT. The odds of previous fetal loss was examined in relation to DDE level in logistic regression models. Compared with women whose DDE level was < 15 mug/L, the adjusted odds ratios of fetal loss according to category of DDE were as follows: 15-29 mug/L, 1.1; 30-44 mug/L, 1.4; 45-59 mug/L, 1.6; and 60 + mug/L, 1.2. The adjusted odds ratio per 60 mug/L increase was 1.4 (95% confidence interval 1.1-1.6). The results were consistent with an adverse effect of DDE on fetal loss, but were inconclusive owing to the possibility that previous pregnancies ending in fetal loss decreased serum DDE levels less than did those carried to term. Published by Elsevier Inc.