The privileged immunity of immune privileged organs: the case of the eye.
The privileged immunity of immune privileged organs: the case of the eye.
复制标题
DOI：
10.3389/fimmu.2012.00296
复制
发表时间：
2012
影响因子：
7.3
通讯作者：
Schwartz M
中科院分区：
文献类型：
--
作者：
Benhar I;London A;Schwartz M
Understanding of ocular diseases and the search for their cure have been based on the common assumption that the eye is an immune privileged site, and the consequent conclusion that entry of immune cells to this organ is forbidden. Accordingly, it was assumed that when immune cell entry does occur, this reflects an undesired outcome of breached barriers. However, studies spanning more than a decade have demonstrated that acute insults to the retina, or chronic conditions resulting in retinal ganglion cell loss, such as in glaucoma, result in an inferior outcome in immunocompromised mice; likewise, steroidal treatment was found to be detrimental under these conditions. Moreover, even conditions that are associated with inflammation, such as age-related macular degeneration, are not currently believed to require immune suppression for treatment, but rather, are thought to benefit from immune modulation. Here, we propose that the immune privilege of the eye is its ability to enable, upon need, the entry of selected immune cells for its repair and healing, rather than to altogether prevent immune cell entry. The implications for acute and chronic degenerative diseases, as well as for infection and inflammatory diseases, are discussed.
登录
查看更多内容
影响因子：
15.8
作者：
Apte, Rajendra S.;Richter, Jennifer;Herndon, John;Ferguson, Thomas A.
通讯作者：
Ferguson, Thomas A.
影响因子：
4.4
作者：
Bakalash, S;Kessler, A;Schwartz, M
通讯作者：
Schwartz, M
影响因子：
5.3
作者：
Kipnis, J;Cardon, M;Schwartz, M
通讯作者：
Schwartz, M
DOI：
10.1523/jneurosci.3257-09.2009
发表时间：
2009-10-28
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Kigerl KA;Gensel JC;Ankeny DP;Alexander JK;Donnelly DJ;Popovich PG
通讯作者：
Popovich PG
影响因子：
5.3
作者：
Fisher, J;Levkovitch-Verbin, H;Schwartz, M
通讯作者：
Schwartz, M