Epigenetic Regulation of miRNAs in Cancer
Epigenetic Regulation of miRNAs in Cancer
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DOI：
10.1007/978-1-4419-9967-2_6
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发表时间：
2013-01-01
期刊：
影响因子：
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通讯作者：
Calin, George A.
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文献类型：
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作者：
Fabbri, Muller;Calore, Federica;Calin, George A.
microRNA（miRNAs）是一类具有基因调控功能的短链非编码RNA。已经证明，编码miRNA的基因经历与蛋白质编码基因相同的调控表观遗传过程。反过来，一个特定的miRNA亚组（称为表观-miRNA）能够直接靶向表观遗传机制的关键酶效应子（例如DNA甲基转移酶、组蛋白脱乙酰酶和polycomb基因），从而间接影响表观遗传调节的癌基因和肿瘤抑制基因的表达。此外，目前批准作为抗癌剂的几种表观遗传药物影响miRNA的表达，这可能解释了它们的部分作用机制。本章重点介绍表观遗传学和miRNAs之间的紧密关系，并提供了一些见解，这些发现的翻译影响，导致即将推出的表观遗传学相关的miRNAs在癌症治疗。
MicroRNAs (miRNAs) are short noncoding RNAs with gene regulatory functions. It has been demonstrated that the genes encoding for miRNAs undergo the same regulatory epigenetic processes of protein coding genes. In turn, a specific subgroup of miRNAs, called epi-miRNAs, is able to directly target key enzymatic effectors of the epigenetic machinery (such as DNA methyltransferases, histone deacetylases, and polycomb genes), therefore indirectly affecting the expression of epigenetically regulated oncogenes and tumor suppressor genes. Also, several of the epigenetic drugs currently approved as anticancer agents affect the expression of miRNAs and this might explain part of their mechanism of action. This chapter focuses on the tight relationship between epigenetics and miRNAs and provides some insights on the translational implications of these findings, leading to the upcoming introduction of epigenetically related miRNAs in the treatment of cancer.