Recruitment and Biological Consequences of Histone Modification of H3K27me3 and H3K9me3
Recruitment and Biological Consequences of Histone Modification of H3K27me3 and H3K9me3
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DOI：
10.1093/ilar.53.3-4.232
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发表时间：
2012-01-01
期刊：
影响因子：
2.5
通讯作者：
Kim, Hana
中科院分区：
文献类型：
--
作者：
Kim, Joomyeong;Kim, Hana
两个组蛋白标记H3K27me3和H3K9me3在后生动物基因组的基因区和非基因区具有抑制作用。已知几种蛋白质复合物负责产生这些标记，包括多梳阻遏复合物2和几种H3K9甲基化酶。最近的研究表明，哺乳动物基因组中这些组蛋白修饰复合物的靶向作用可能通过几种DNA结合蛋白介导，包括AEBP 2，JARID 2和YY 1。在这篇综述中，我们讨论了潜在的靶向机制，根据最近的结果，已来自全基因组染色质免疫沉淀测序数据和在体内的功能，这两个组蛋白标记的结果来自小鼠和人类的遗传研究。
Two histone marks, H3K27me3 and H3K9me3, are well known for their repressive roles in the genic and nongenic regions of metazoan genomes. Several protein complexes are known to be responsible for generating these marks, including polycomb repression complex 2 and several H3K9 methylases. Recent studies have shown that the targeting of these histone-modifying complexes within mammalian genomes may be mediated through several DNA-binding proteins, including AEBP2, JARID2, and YY1. In this review, we discuss the potential targeting mechanisms in light of the recent results that have been derived from genome-wide chromatin immunoprecipitation sequencing data and the in vivo functions of these two histone marks in light of the results derived from mouse and human genetic studies.