Human epididymis protein 4 in endometrial cancer: A meta-analysis1
Human epididymis protein 4 in endometrial cancer: A meta-analysis1
复制标题
子宫内膜癌中的人附睾蛋白 4：荟萃分析1
作者：
Li LM;Zhu YX;Zhong Y;Su T;Fan XM;Xi Q;Li MY;Fu J;Tan H;Liu S
背景：血清人附睾蛋白4（HE 4）是子宫内膜癌（EC）的潜在标志物，但其对EC的诊断价值仍存在争议。在这项研究中，我们进行了荟萃分析，以评估血清HE 4诊断EC的准确性。方法：利用在线数据库系统鉴定血清HE 4诊断EC准确性的文献报道。使用STATA 12.0、Meta-Disc 1.4和Review Manager 5.2进行荟萃分析。结果：共有4182名参与者和23项研究被纳入我们的荟萃分析。合并敏感性（SEN）、特异性（SPE）、阳性似然比（PLR）、阴性似然比（NLR）、诊断比值比（DOR）和曲线下面积（AUC）为0.65（95% CI：0.56-0.73），0.91（95% CI：0.84-0.95）、（95% CI：4.38-12.64）、0.38（95% CI：0.31-0.47）、19.46（95% CI：11.61-32.62）和0.84（95% CI：0.81 - 0.87）。我们的综合分析表明，HE 4是一个有用的诊断指标EC。亚组分析表明，良性疾病对照组的研究显示出比健康对照组更高的诊断准确性。结论：血清HE 4可作为诊断EC的潜在生物标志物。由于存在一定的局限性，这一结论应谨慎解释。
BACKGROUND:.Serum human epididymis protein 4 (HE4) is a potential marker for endometrial cancer (EC), however, the diagnostic value of HE4 for EC remains controversial. In this study, we performed a meta-analysis to estimate the diagnostic accuracy of serum HE4 for EC...METHODS:.Literature reports of the diagnostic accuracy of serum HE4 for EC were systematically identified using online data-bases. The meta-analysis was performed using STATA 12.0, Meta-Disc 1.4, and Review Manager 5.2...RESULTS:.A total of 4182 participants and 23 studies were included in our meta-analysis. The pooled sensitivity (SEN), specificity (SPE), positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and area under the curve (AUC) were 0.65 (95% CI: 0.56-0.73), 0.91 (95% CI: 0.84-0.95), (95% CI: 4.38-12.64), 0.38 (95% CI: 0.31-0.47), 19.46 (95% CI: 11.61-32.62) and 0.84 (95% CI: 0.81 to 0.87), respectively. Our overall analysis suggested that HE4 is a useful diagnostic marker for EC. Subgroup analysis indicated that studies with benign disease controls showed higher diagnostic accuracies than those with healthy controls...CONCLUSION:.Serum HE4 may serve as a potential biomarker for EC diagnosis. Due to certain limitations, this conclusion should to be cautiously interpreted.