ICE-related proteases in apoptosis
ICE-related proteases in apoptosis
复制标题
DOI：
10.1016/s0959-437x(96)90010-6
复制
发表时间：
1996-02-01
影响因子：
4
通讯作者：
Earnshaw, WC
中科院分区：
文献类型：
--
作者：
Takahashi, A;Earnshaw, WC
细胞凋亡的执行涉及许多酶途径，所有这些途径似乎都是由一种或多种ICE相关蛋白酶（IRP）的激活触发的。目前，在快速扩展的IRP超家族的鉴定和功能表征方面正在付出相当大的努力。仍然未解决的重要问题包括脊椎动物IRP的身份，触发细胞凋亡级联和身份的关键底物，其裂解结果在细胞凋亡过程中的戏剧性的形态变化。
Apoptotic execution involves numerous enzymatic pathways, all of which appear to be triggered by the activation of one or more ICE-related proteases (IRPs). Considerable effort is currently being expended in the identification and functional characterization of the rapidly expanding superfamily of IRPs. Important questions that remain unsolved include the identity of the vertebrate IRP that triggers the apoptotic cascade and the identities of the crucial substrates whose cleavage results in the dramatic morphological changes during apoptosis.