Refractory bullous pemphigoid leaving numerous milia during recovery
Refractory bullous pemphigoid leaving numerous milia during recovery
复制标题
DOI：
10.1111/1346-8138.12650
复制
发表时间：
2014-11-01
影响因子：
3.1
通讯作者：
Kawada, Akira
中科院分区：
文献类型：
--
作者：
Uchida, Shusuke;Oiso, Naoki;Kawada, Akira
大疱性类天疱疮(BP)、粘膜类天疱疮(MMP)和获得性大疱性表皮松解症(EBA)可出现Milia的恢复。瘢痕形成通常发生在基质金属蛋白酶和子宫内膜癌中。在这里，我们报告一名62岁的男性BP患者，他在康复过程中留下了大量的Milia。患者具有针对BP180-NC16a结构域重组蛋白和BP180可溶性120 kDa胞外结构域(线状IgA大疱性皮肤病[LAD]-1)的免疫球蛋白G自身抗体。有抗LAD-1自身抗体和/或BP180 C端区重组蛋白阳性的BP病例。恢复期广泛的粟粒形成可能与免疫易感性和/或半桥粒与细胞外基质成分的不适当相互作用有关。
Recovery with milia may occur in bullous pemphigoid (BP), mucous membrane pemphigoid (MMP) and epidermolysis bullosa acquisita (EBA). Scarring commonly occurs in MMP and EBA. Here, we report a 62-year-old man patient with BP, who was left with numerous milia during recovery. The patient had immunoglobulin (Ig)G autoantibodies to the recombinant protein of the BP180-NC16a domain and the soluble 120-kDa ectodomain of BP180 (linear IgA bullous dermatosis [LAD]-1). There are cases of BP with IgG autoantibodies to LAD-1 and/or the recombinant protein of BP180 C-terminal domain. Extensive milia formation during recovery may be associated with immunological predisposition and/or improper interaction between hemidesmosomes and the extracellular matrix components.