Hearing loss in ankylosing spondylitis
Hearing loss in ankylosing spondylitis
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DOI：
10.1111/1756-185x.13560
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发表时间：
2019-07-01
影响因子：
2.5
通讯作者：
Lawrence, Able
中科院分区：
文献类型：
--
作者：
Ajmani, Sajal;Keshri, Amit;Lawrence, Able
目的强直性脊柱炎（AS）患者存在感音神经性耳聋，而传导性耳聋则较为罕见。在我们的研究中，我们研究了AS患者听力损失（HL）的患病率及其与非甾体抗炎药（NSAID）摄入量的关系。方法对100例AS患者和40例正常对照者进行研究。HL定义为纯音听阈在听力图中至少两个频率大于20 dB（分贝）。HL的严重程度由世界卫生组织定义。记录临床详情和累积NSAID剂量。结果100例患者中96例为男性，平均年龄32 ± 12岁，平均病程8.2 ± 6年。中位Bath强直性脊柱炎疾病活动指数（BASDAI）、Bath强直性脊柱炎功能指数（BASFI）、Bath强直性脊柱炎计量指数（BASMI）和累积NSAID剂量分别为3.5 +/- 2.2、2.75 +/- 2、3.7 +/- 2.6和1202 +/- 1290。在48例HL患者中，28例患者患有双侧HL。29例患者为纯传导性HL，16例为混合性HL（感觉和传导性成分），3例为纯感觉神经性HL。38例患者的HL为轻度，10例患者为中度至重度。HL的存在与较高的年龄有关（P
Aim Several studies have described sensorineural deafness in ankylosing spondylitis (AS) patients while conductive hearing loss has been reported to be rare. In our study we have studied the prevalence of hearing loss (HL) among AS patients and its association with non-steroidal anti-inflammatory drug (NSAID) intake. Methods We studied 100 AS patients and 40 controls. HL was defined as pure-tone thresholds greater than 20 dB (decibel) in at least two frequencies of the audiogram. Severity of HL was defined as given by World Health Organization. Clinical details and cumulative NSAID doses were noted. Results Ninety-six of the 100 patients were male with mean age of 32 +/- 12 years and mean duration of illness of 8.2 +/- 6 years. Median Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index (BASFI), Bath Ankylosing Spondylitis Metrology Index (BASMI) and cumulative NSAID dose were 3.5 +/- 2.2, 2.75 +/- 2, 3.7 +/- 2.6 and 1202 +/- 1290, respectively. Of the 48 with HL, 28 patients had bilateral HL. Twenty-nine patients had pure conductive HL while 16 had mixed HL (components of both sensory and conductive) and 3 had pure sensorineural HL. HL was mild in 38 patients, and moderate to severe in 10 patients. The presence of HL was associated with higher age (P