Temporal integration of intracellular Ca2+ signaling networks in regulating gene expression by action potentials
Temporal integration of intracellular Ca2+ signaling networks in regulating gene expression by action potentials
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DOI：
10.1016/j.ceca.2005.01.011
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发表时间：
2005-05-01
期刊：
影响因子：
4
通讯作者：
Cohen, JE
中科院分区：
文献类型：
--
作者：
Fields, RD;Lee, PR;Cohen, JE
细胞内钙信号传导的时间方面在神经元中基因表达的活性依赖性调节中特别重要。这篇评论跟踪钙依赖的细胞内信号从膜到细胞核的反应动作电位发射，并考虑如何特定的基因调控的特定模式的脉冲发射。钙内流，钙依赖性蛋白激酶，转录因子，个别基因和基因组分析的模式进行检查，特别强调在调节这些过程中的钙动力学的时间方面的重要性。爱思唯尔有限公司出版
Temporal aspects of intracellular calcium signaling are particularly important in activity-dependent regulation of gene expression in neurons. This review traces calcium-dependent intracellular signaling from the membrane to the nucleus in response to action-potential firing, and considers how specific genes are regulated by specific patterns of impulse firing. Modes of calcium influx, calcium-dependent protein kinases, transcription factors, individual genes, and genomic analysis are examined, with particular emphasis on the importance of temporal aspects of calcium dynamics in regulating these processes. Published by Elsevier Ltd.