Study of cardiovascular function using a coupled left ventricle and systemic circulation model.
Study of cardiovascular function using a coupled left ventricle and systemic circulation model.
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DOI：
10.1016/j.jbiomech.2016.03.009
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发表时间：
2016-08-16
影响因子：
2.4
通讯作者：
Hill NA
中科院分区：
文献类型：
--
作者：
Chen WW;Gao H;Luo XY;Hill NA
为了深入了解心脏-动脉相互作用，开发了一种耦合左心室-体动脉（LV-SA）模型，该模型包含三维有限应变左心室（LV）和基于生理学的体动脉（SA）一维模型。LV模型和SA模型的耦合通过匹配主动脉根部处的压力和流速来实现，即SA模型将压力作为边界条件反馈给LV模型，并且来自LV模型的主动脉流速用作SA模型的输入。耦合系统的控制方程求解采用组合浸没边界有限元（IB/FE）方法和Lax-Wendroff格式。一个基线情况下，使用生理测量的健康受试者，和四个范例的情况下，基于不同的生理和病理的情况下，使用LV-SA模型进行了研究。基线情况下的结果与已发表的实验数据吻合良好。这四个典型病例预测了心血管系统的各种病理反应，这也得到了临床观察的支持。新模型可用于深入了解一系列临床应用中的心动脉相互作用。
To gain insight into cardio-arterial interactions, a coupled left ventricle-systemic artery (LV–SA) model is developed that incorporates a three-dimensional finite-strain left ventricle (LV), and a physiologically-based one-dimensional model for the systemic arteries (SA). The coupling of the LV model and the SA model is achieved by matching the pressure and the flow rate at the aortic root, i.e. the SA model feeds back the pressure as a boundary condition to the LV model, and the aortic flow rate from the LV model is used as the input for the SA model. The governing equations of the coupled system are solved using a combined immersed-boundary finite-element (IB/FE) method and a Lax–Wendroff scheme. A baseline case using physiological measurements of healthy subjects, and four exemplar cases based on different physiological and pathological scenarios are studied using the LV–SA model. The results of the baseline case agree well with published experimental data. The four exemplar cases predict varied pathological responses of the cardiovascular system, which are also supported by clinical observations. The new model can be used to gain insight into cardio-arterial interactions across a range of clinical applications.