EFFECTS OF MICROGRAVITY OR SIMULATED LAUNCH ON TESTICULAR FUNCTION IN RATS
EFFECTS OF MICROGRAVITY OR SIMULATED LAUNCH ON TESTICULAR FUNCTION IN RATS
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DOI：
10.1152/jappl.1992.73.2.s174
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发表时间：
1992-08-01
影响因子：
3.3
通讯作者：
WILLIAMS, CS
中科院分区：
文献类型：
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作者：
AMANN, RP;DEAVER, DR;WILLIAMS, CS
通过主观和定量方法分析COSMOS 2044上的飞行大鼠和模拟发射、动物园或尾抬高对照大鼠（5只/组）的睾丸。根据固定组织的观察结果，很明显，一些大鼠存在与给药无关的睾丸异常，并且在将其随机分配至4个给药组时可能存在睾丸异常。考虑到大鼠没有预先存在的异常，曲细精管的直径和每个小管横截面的生殖细胞数在飞行中低于（P < 0.05）在模拟发射或动物园大鼠。然而，生殖细胞的比例，彼此或支持细胞和抗均质化精子细胞的数量并没有不同的值模拟发射或动物园控制。睾丸特异性基因产物的表达没有很大的改变飞行。此外，没有证据表明产生应激诱导的hsp 70或hsp 90基因转录本。飞行和模拟发射大鼠睾丸组织黄体生成素受体浓度和间质细胞滑面内质网面密度相似。飞行至2 wk大鼠睾丸组织和外周血睾酮水平均显著降低（P < 0.05），这可能是飞行后睾丸组织和外周血睾酮水平进一步降低的原因。应考虑与微重力有关的雄激素产生减少对肌肉和骨骼周转的影响。
Testes from flight rats on COSMOS 2044 and simulated-launch, vivarium, or caudal-elevation control rats (5/group) were analyzed by subjective and quantitative methods. On the basis of observations of fixed tissue, it was evident that some rats had testicular abnormalities unassociated with treatment and probably existing when they were assigned randomly to the four treatment groups. Considering rats without preexisting abnormalities, diameter of seminiferous tubules and numbers of germ cells per tubule cross section were lower (P < 0.05) in flight than in simulated-launch or vivarium rats. However, ratios of germ cells to each other or to Sertoli cells and number of homogenization-resistant spermatids did not differ from values for simulated-launch or vivarium controls. Expression of testis-specific gene products was not greatly altered by flight. Furthermore, there was no evidence for production of stress-inducible transcripts of the hsp70 or hsp90 genes. Concentration of receptors for rat luteinizing hormone in testicular tissue and surface density of smooth endoplasmic reticulum in Leydig cells were similar in flight and simulated-launch rats. However, concentrations of testosterone in testicular tissue or peripheral blood plasma were reduced (P < 0.05) in flight rats to 2 wk might result in additional changes. Sequelae of reduced androgen production associated with microgravity on turnover of muscle and bone should be considered.